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  1. Functional lateralization is a conserved feature of the central nervous system (CNS). However, underlying left-right asymmetries within neural circuitry and the mechanisms by which they develop are poorly desc...

    Authors: Isaac H Bianco, Matthias Carl, Claire Russell, Jonathan DW Clarke and Stephen W Wilson

    Citation: Neural Development 2008 3:9

    Content type: Research article

    Published on:

  4. How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood. We have taken advantage of the unique featur...

    Authors: Marc A Wolman, Vinoth K Sittaramane, Jeffrey J Essner, H Joseph Yost, Anand Chandrasekhar and Mary C Halloran

    Citation: Neural Development 2008 3:6

    Content type: Research article

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  5. In the mammalian brain, neural stem cells divide asymmetrically and often amplify the number of progeny they generate via symmetrically dividing intermediate progenitors. Here we investigate whether specific n...

    Authors: Bruno C Bello, Natalya Izergina, Emmanuel Caussinus and Heinrich Reichert

    Citation: Neural Development 2008 3:5

    Content type: Research article

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  6. During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate. Two main factors will determi...

    Authors: Valérie Lobjois, Sophie Bel-Vialar, Françoise Trousse and Fabienne Pituello

    Citation: Neural Development 2008 3:4

    Content type: Research article

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  7. Drosophila has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. Mutations in all five affect axon guidance, either alone or in combination. Highly penetrant ce...

    Authors: Mili Jeon, Huong Nguyen, Sami Bahri and Kai Zinn

    Citation: Neural Development 2008 3:3

    Content type: Research article

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  8. Retinal bipolar cells comprise a diverse group of neurons. Cone bipolar cells and rod bipolar cells are so named for their connections with cone and rod photoreceptors, respectively. Morphological criteria hav...

    Authors: Eric M Morrow, C-M Amy Chen and Constance L Cepko

    Citation: Neural Development 2008 3:2

    Content type: Research article

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  10. During spinal cord development, expression of chicken SEMAPHORIN6A (SEMA6A) is almost exclusively found in the boundary caps at the ventral motor axon exit point and at the dorsal root entry site. The boundary...

    Authors: Olivier Mauti, Elena Domanitskaya, Irwin Andermatt, Rejina Sadhu and Esther T Stoeckli

    Citation: Neural Development 2007 2:28

    Content type: Research article

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  11. The SCFskp2 complex is an E3 ubiquitin ligase that is known to target a number of cell cycle regulators, including cyclin-dependent kinase inhibitors, for proteolysis. While its role in regulation of cell divisio...

    Authors: Hector Boix-Perales, Ian Horan, Helen Wise, Horng-Ru Lin, Li-Chiou Chuang, P Renee Yew and Anna Philpott

    Citation: Neural Development 2007 2:27

    Content type: Research article

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  13. The developing vertebrate brain is patterned first by global signalling gradients that define crude anteroposterior and dorsoventral coordinates, and subsequently by local signalling centres (organisers) that ...

    Authors: Maria Flavia Guinazu, David Chambers, Andrew Lumsden and Clemens Kiecker

    Citation: Neural Development 2007 2:25

    Content type: Research article

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  14. The left and right AWC olfactory neurons in Caenorhabditis elegans differ in their functions and in their expression of chemosensory receptor genes; in each animal, one AWC randomly takes on one identity, designa...

    Authors: Sarah L Bauer Huang, Yasunori Saheki, Miri K VanHoven, Ichiro Torayama, Takeshi Ishihara, Isao Katsura, Alexander van der Linden, Piali Sengupta and Cornelia I Bargmann

    Citation: Neural Development 2007 2:24

    Content type: Research article

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  15. In vertebrates, the primordium of the brain is subdivided by the expression of Otx genes (forebrain/anterior midbrain), Hox genes (posterior hindbrain), and the genes Pax2, Pax5 and Pax8 (intervening region). ...

    Authors: Rolf Urbach

    Citation: Neural Development 2007 2:23

    Content type: Research article

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  16. The Drosophila leucine-rich repeat proteins Tartan (TRN) and Capricious (CAPS) mediate cell affinity differences during compartition of the wing imaginal disc. This study aims to identify and characterize the exp...

    Authors: Laura C Andreae, Daniela Peukert, Andrew Lumsden and Jonathan D Gilthorpe

    Citation: Neural Development 2007 2:22

    Content type: Research article

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  17. In developing neurons, somal migration and initiation of axon outgrowth often occur simultaneously and are regulated in part by similar classes of molecules. When neurons reach their final destinations, howeve...

    Authors: Romke Bron, Matthieu Vermeren, Natalie Kokot, William Andrews, Graham E Little, Kevin J Mitchell and James Cohen

    Citation: Neural Development 2007 2:21

    Content type: Research article

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  18. Odors are detected by sensory neurons that carry information to the olfactory lobe where they connect to projection neurons and local interneurons in glomeruli: anatomically well-characterized structures that ...

    Authors: Bidisha Roy, Ajeet P Singh, Chetak Shetty, Varun Chaudhary, Annemarie North, Matthias Landgraf, K VijayRaghavan and Veronica Rodrigues

    Citation: Neural Development 2007 2:20

    Content type: Research article

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  19. Little is known about the involvement of molecular determinants of segmental patterning of rhombomeres (r) in the development of rhythmic neural networks in the mouse hindbrain. Here, we compare the phenotypes...

    Authors: Fabrice Chatonnet, Ludovic J Wrobel, Valérie Mézières, Massimo Pasqualetti, Sébastien Ducret, Emmanuel Taillebourg, Patrick Charnay, Filippo M Rijli and Jean Champagnat

    Citation: Neural Development 2007 2:19

    Content type: Research article

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  20. The WAVE/SCAR complex, consisting of CYFIP (PIR121 or Sra1), Kette (Nap1), Abi, SCAR (WAVE) and HSPC300, is known to regulate the actin nucleating Arp2/3 complex in a Rac1-dependent manner. While in vitro and in ...

    Authors: Abrar Qurashi, H Bahar Sahin, Pilar Carrera, Alexis Gautreau, Annette Schenck and Angela Giangrande

    Citation: Neural Development 2007 2:18

    Content type: Research article

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  21. How specific are the synaptic connections formed as neuronal networks develop and can simple rules account for the formation of functioning circuits? These questions are assessed in the spinal circuits control...

    Authors: Wen-Chang Li, Tom Cooke, Bart Sautois, Stephen R Soffe, Roman Borisyuk and Alan Roberts

    Citation: Neural Development 2007 2:17

    Content type: Research article

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  22. The growth of new synapses shapes the initial formation and subsequent rearrangement of neural circuitry. Genetic studies have demonstrated that the ubiquitin ligase Highwire restrains synaptic terminal growth...

    Authors: Chunlai Wu, Richard W Daniels and Aaron DiAntonio

    Citation: Neural Development 2007 2:16

    Content type: Research article

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  23. The meeting 'From sensory perception to motor output: genetic bases of behavior in the zebrafish embryo' was held at Minerve (South of France) on March 16–18, 2007. The meeting site was beautifully situated in...

    Authors: Alain Ghysen, Christine Dambly-Chaudière and David Raible

    Citation: Neural Development 2007 2:15

    Content type: Meeting report

    Published on:

  24. Precise connections of neural circuits can be specified by genetic programming. In the Drosophila olfactory system, projection neurons (PNs) send dendrites to single glomeruli in the antenna lobe (AL) based upon ...

    Authors: Maria Lynn Spletter, Jian Liu, Justin Liu, Helen Su, Edward Giniger, Takaki Komiyama, Stephen Quake and Liqun Luo

    Citation: Neural Development 2007 2:14

    Content type: Research article

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  26. Otx genes, orthologues of the Drosophila orthodenticle gene (otd), play crucial roles in vertebrate brain development. In the Xenopus eye, Xotx2 and Xotx5b promote bipolar and photoreceptor cell fates, respective...

    Authors: Marco Onorati, Federico Cremisi, Yang Liu, Rong-Qiao He, Giuseppina Barsacchi and Robert Vignali

    Citation: Neural Development 2007 2:12

    Content type: Research article

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  27. Organs are programmed to acquire a particular size during development, but the regulatory mechanisms that dictate when dividing progenitor cells should permanently exit the cell cycle and stop producing additi...

    Authors: Lin Ma, Robert Cantrup, Annie Varrault, Dilek Colak, Natalia Klenin, Magdalena Götz, Sarah McFarlane, Laurent Journot and Carol Schuurmans

    Citation: Neural Development 2007 2:11

    Content type: Research article

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  28. Telencephalic patterning centers, defined by the discrete expression domains of distinct morphogens, Fgf s in the commissural plate (CoP), Wnt s and Bmp s in the cortical hem, and a ventral domain of Sonic hedgeh...

    Authors: Setsuko Sahara, Yasuhiko Kawakami, Juan Carlos Izpisua Belmonte and Dennis DM O'Leary

    Citation: Neural Development 2007 2:10

    Content type: Research article

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  30. The forebrain consists of multiple structures necessary to achieve elaborate functions. Proper patterning is, therefore, a prerequisite for the generation of optimal functional areas. Only a few factors have b...

    Authors: Andreas Zembrzycki, Gundula Griesel, Anastasia Stoykova and Ahmed Mansouri

    Citation: Neural Development 2007 2:8

    Content type: Research article

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  31. Proper neuronal function depends on forming three primary subcellular compartments: axons, dendrites, and soma. Each compartment has a specialized function (the axon to send information, dendrites to receive i...

    Authors: Melissa M Rolls, Daisuke Satoh, Peter J Clyne, Astra L Henner, Tadashi Uemura and Chris Q Doe

    Citation: Neural Development 2007 2:7

    Content type: Research article

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  33. During the embryonic development of the cerebellum, neurons are produced from progenitor cells located along a ventricular zone within dorsal rhombomere 1 that extends caudally to the roof plate of the fourth ...

    Authors: Robert P Machold, Deborah Jones Kittell and Gordon J Fishell

    Citation: Neural Development 2007 2:5

    Content type: Research article

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  34. Extracellular signaling through receptors for neurotrophins mediates diverse neuronal functions, including survival, migration and differentiation in the central nervous system, but the transcriptional targets...

    Authors: Anna Maria Calella, Claus Nerlov, Rodolphe G Lopez, Carla Sciarretta, Oliver von Bohlen und Halbach, Oksana Bereshchenko and Liliana Minichiello

    Citation: Neural Development 2007 2:4

    Content type: Research article

    Published on:

  35. General somatic sensation is conveyed to the central nervous system at cranial levels by the trigeminal ganglion (TG), and at spinal levels by the dorsal root ganglia (DRG). Although these ganglia have similar...

    Authors: S Raisa Eng, Iain M Dykes, Jason Lanier, Natalia Fedtsova and Eric E Turner

    Citation: Neural Development 2007 2:3

    Content type: Research article

    Published on:

  36. Modifications in Pax6 homeogene expression produce strong eye phenotypes. This suggested to us that eye development might be an appropriate model to verify if homeoprotein intercellular passage has important func...

    Authors: Brigitte Lesaffre, Alain Joliot, Alain Prochiantz and Michel Volovitch

    Citation: Neural Development 2007 2:2

    Content type: Research article

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  37. The choice of a stem cell to divide symmetrically or asymmetrically has profound consequences for development and disease. Unregulated symmetric division promotes tumor formation, whereas inappropriate asymmet...

    Authors: Boris Egger, Jason Q Boone, Naomi R Stevens, Andrea H Brand and Chris Q Doe

    Citation: Neural Development 2007 2:1

    Content type: Research article

    Published on:

  39. While developmental processes such as axon pathfinding and synapse formation have been characterized in detail, comparatively less is known of the intrinsic developmental mechanisms that regulate transcription...

    Authors: Edward CG Pym, Tony D Southall, Christopher J Mee, Andrea H Brand and Richard A Baines

    Citation: Neural Development 2006 1:3

    Content type: Research article

    Published on:

  40. In the absence of external cues, neurons in vitro polarize by using intrinsic mechanisms. For example, cultured hippocampal neurons extend arbitrarily oriented neurites and then one of these, usually the one near...

    Authors: Flavio R Zolessi, Lucia Poggi, Christopher J Wilkinson, Chi-Bin Chien and William A Harris

    Citation: Neural Development 2006 1:2

    Content type: Research article

    Published on:

Editors-in-Chief

Chris Doe
University of Oregon, USA
Julia Kaltschmidt
Stanford University, USA
Kang Shen
Stanford University, USA

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Neural Development

ISSN: 1749-8104