Chris Doe
University of Oregon, USA
Articles
Page 1 of 9
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Citation: Neural Development 2023 18:4
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Correction: Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life
Citation: Neural Development 2023 18:3 -
Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition
The mammalian somatosensory system is comprised of multiple neuronal populations that form specialized, highly organized sensory endings in the skin. The organization of somatosensory endings is essential to t...
Citation: Neural Development 2023 18:2 -
Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation
We previously identified Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) as a marker of long-term neurogenic stem cells in the lateral wall of the adult mouse brain. The morphology of the stem cell...
Citation: Neural Development 2023 18:1 -
Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development
Neurons are highly specialized cells with a complex morphology generated by various membrane trafficking steps. They contain Golgi outposts in dendrites, which are formed from somatic Golgi tubules. In traffic...
Citation: Neural Development 2022 17:12 -
Correction: A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages
Citation: Neural Development 2022 17:11 -
Dpr10 and Nocte are required for Drosophila motor axon pathfinding
The paths axons travel to reach their targets and the subsequent synaptic connections they form are highly stereotyped. How cell surface proteins (CSPs) mediate these processes is not completely understood. The D...
Citation: Neural Development 2022 17:10 -
mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in metazoans and is particularly abundant in the central nervous system. The extent to which m6A is dynamically regulated and whether m6A....
Citation: Neural Development 2022 17:9 -
A single-cell transcriptomic atlas of complete insect nervous systems across multiple life stages
Molecular profiles of neurons influence neural development and function but bridging the gap between genes, circuits, and behavior has been very difficult. Here we used single cell RNAseq to generate a complet...
Citation: Neural Development 2022 17:8 -
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts
The mechanisms that generate neural diversity during development remains largely unknown. Here, we use scRNA-seq methodology to discover new features of the Drosophila larval CNS across several key developmental ...
Citation: Neural Development 2022 17:7 -
Early development of the cochlea of the common marmoset, a non-human primate model
Fine-tuned cochlear development is essential for hearing. Owing to the difficulty in using early human fetal samples, most of our knowledge regarding cochlear development has been obtained from rodents. Howeve...
Citation: Neural Development 2022 17:6 -
DSCAM is differentially patterned along the optic axon pathway in the developing Xenopus visual system and guides axon termination at the target
The Xenopus retinotectal circuit is organized topographically, where the dorsal–ventral axis of the retina maps respectively on to the ventral-dorsal axis of the tectum; axons from the nasal-temporal axis of the ...
Citation: Neural Development 2022 17:5 -
Correction to: Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting
Citation: Neural Development 2022 17:4 -
Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts
Neural progenitors produce diverse cells in a stereotyped birth order, but can specify each cell type for only a limited duration. In the Drosophila embryo, neuroblasts (neural progenitors) specify multiple, dist...
Citation: Neural Development 2022 17:3 -
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
The molecular signaling pathway, Sonic hedgehog (Shh), is critical for the proper development of the central nervous system. The requirement for Shh signaling in neuronal and oligodendrocyte development in the...
Citation: Neural Development 2022 17:2 -
Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting
Olfactory Sensory Neuron (OSN) axons project from the zebrafish olfactory epithelium to reproducible intermediate target locations in the olfactory bulb called protoglomeruli at early stages in development. Tw...
Citation: Neural Development 2022 17:1 -
The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination
Myelination is a highly regulated process in the vertebrate central nervous system (CNS) whereby oligodendrocytes wrap axons with multiple layers of insulating myelin in order to allow rapid electrical conduct...
Citation: Neural Development 2021 16:6 -
Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification
While the transcriptional code governing retinal ganglion cell (RGC) type specification begins to be understood, its interplay with neurotrophic signaling is largely unexplored. In mice, the transcription fact...
Citation: Neural Development 2021 16:5 -
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons
The development of functional neural circuits requires the precise formation of synaptic connections between diverse neuronal populations. The molecular pathways that allow GABAergic interneuron subtypes in th...
Citation: Neural Development 2021 16:4 -
A two-step actin polymerization mechanism drives dendrite branching
Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched de...
Citation: Neural Development 2021 16:3 -
Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis
The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to ...
Citation: Neural Development 2021 16:2 -
The role of astrocyte‐mediated plasticity in neural circuit development and function
Neuronal networks are capable of undergoing rapid structural and functional changes called plasticity, which are essential for shaping circuit function during nervous system development. These changes range fr...
Citation: Neural Development 2021 16:1 -
Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex
Developing cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen specific synaptic connections during circuit formation. Nectin-3 is a cell...
Citation: Neural Development 2020 15:13 -
Individual neuronal subtypes control initial myelin sheath growth and stabilization
In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axo...
Citation: Neural Development 2020 15:12 -
Synapse development and maturation at the drosophila neuromuscular junction
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural circuits that underlie all animal cognition and behavior. Chemical synapses are specialized asymmetric junctions betwee...
Citation: Neural Development 2020 15:11 -
The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction
Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is protecte...
Citation: Neural Development 2020 15:10 -
A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage
Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate “cardinal class...
Citation: Neural Development 2020 15:9 -
Association between rare variants in specific functional pathways and human neural tube defects multiple subphenotypes
Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to e...
Citation: Neural Development 2020 15:8 -
The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance
Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work...
Citation: Neural Development 2020 15:7 -
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease
Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress ma...
Citation: Neural Development 2020 15:6 -
Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells
The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-...
Citation: Neural Development 2020 15:5 -
Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function
Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-ass...
Citation: Neural Development 2020 15:4 -
Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life
Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) regulates stem cell quiescence. As a marker, it identifies stem cells in multiple organs of the mouse. We had detected Lrig1 expression in cultured I...
Citation: Neural Development 2020 15:3 -
An inducible Cre mouse line to sparsely target nervous system cells, including Remak Schwann cells
Nerves of the peripheral nervous system contain two classes of Schwann cells: myelinating Schwann cells that ensheath large caliber axons and generate the myelin sheath, and Remak Schwann cells that surround s...
Citation: Neural Development 2020 15:2 -
Evaluating the effectiveness of anti-Nogo treatment in spinal cord injuries
As humans, we cannot regenerate axons within the central nervous system (CNS), therefore, making any damage to it permanent. This leads to the loss of sensory and motor function below the site of injury and ca...
Citation: Neural Development 2020 15:1 -
Microglia in the developing retina
Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in par...
Citation: Neural Development 2019 14:12 -
The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an orga...
Citation: Neural Development 2019 14:11 -
sli is required for proper morphology and migration of sensory neurons in the Drosophila PNS
Neurons and glial cells coordinate with each other in many different aspects of nervous system development. Both types of cells are receiving multiple guidance cues to guide the neurons and glial cells to thei...
Citation: Neural Development 2019 14:10 -
Commissural axon guidance in the developing spinal cord: from Cajal to the present day
During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic...
Citation: Neural Development 2019 14:9 -
Cellular properties of intrinsically photosensitive retinal ganglion cells during postnatal development
Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) respond directly to light and have been shown to mediate a broad variety of visual behaviors in adult animals. ipRGCs are als...
Citation: Neural Development 2019 14:8 -
Timing the spinal cord development with neural progenitor cells losing their proliferative capacity: a theoretical analysis
In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of th...
Citation: Neural Development 2019 14:7 -
Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse
Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of here...
Citation: Neural Development 2019 14:6 -
Zebrafish prdm12b acts independently of nkx6.1 repression to promote eng1b expression in the neural tube p1 domain
Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor circuits form in distinct domains along the dorsoventral...
Citation: Neural Development 2019 14:5 -
Genetic deletion of genes in the cerebellar rhombic lip lineage can stimulate compensation through adaptive reprogramming of ventricular zone-derived progenitors
The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependen...
Citation: Neural Development 2019 14:4 -
TrkB expression and dependence divides gustatory neurons into three subpopulations
During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate ...
Citation: Neural Development 2019 14:3 -
An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development
Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun...
Citation: Neural Development 2019 14:2 -
Degeneration of saccular hair cells caused by MITF gene mutation
Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. P...
Citation: Neural Development 2019 14:1 -
The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus
The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensi...
Citation: Neural Development 2018 13:27 -
Identification and characterization of early photoreceptor cis-regulatory elements and their relation to Onecut1
Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors o...
Citation: Neural Development 2018 13:26 -
Dynamic Notch signalling regulates neural stem cell state progression in the Drosophila optic lobe
Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells p...
Citation: Neural Development 2018 13:25
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