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  1. Short report

    Neocortical Sox9+ radial glia generate glutamatergic neurons for all layers, but lack discernible evidence of early laminar fate restriction

    Glutamatergic neurons in the cerebral cortex are derived from embryonic neural stem cells known as radial glial progenitors (RGPs). Early RGPs, present at the onset of cortical neurogenesis, are classically th...

    E. S. Kaplan, K. A. Ramos-Laguna, A. B. Mihalas, R. A. M. Daza and R. F. Hevner

    Neural Development 2017 12:14

    Published on: 16 August 2017

  2. Research article

    Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2

    Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminen...

    Shenyue Qin, Stephanie M. Ware, Ronald R. Waclaw and Kenneth Campbell

    Neural Development 2017 12:13

    Published on: 16 August 2017

  3. Research article

    The emergence of mesencephalic trigeminal neurons

    The cells of the mesencephalic trigeminal nucleus (MTN) are the proprioceptive sensory neurons that innervate the jaw closing muscles. These cells differentiate close to the two key signalling centres that inf...

    Marcela Lipovsek, Julia Ledderose, Thomas Butts, Tanguy Lafont, Clemens Kiecker, Andrea Wizenmann and Anthony Graham

    Neural Development 2017 12:11

    Published on: 21 June 2017

  4. Research article

    Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord

    In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also the...

    Julien Laussu, Christophe Audouard, Anthony Kischel, Poincyane Assis-Nascimento, Nathalie Escalas, Daniel J. Liebl, Cathy Soula and Alice Davy

    Neural Development 2017 12:10

    Published on: 8 June 2017

  5. Short Report

    Astroglial-mediated remodeling of the interhemispheric midline during telencephalic development is exclusive to eutherian mammals

    The corpus callosum forms the major interhemispheric connection in the human brain and is unique to eutherian (or placental) mammals. The developmental events associated with the evolutionary emergence of this...

    Ilan Gobius, Rodrigo Suárez, Laura Morcom, Annalisa Paolino, Timothy J. Edwards, Peter Kozulin and Linda J. Richards

    Neural Development 2017 12:9

    Published on: 30 May 2017

  6. Short Report

    Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex

    During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriatel...

    Olivier Clément, Isabel Anne Hemming, Ivan Enghian Gladwyn-Ng, Zhengdong Qu, Shan Shan Li, Michael Piper and Julian Ik-Tsen Heng

    Neural Development 2017 12:8

    Published on: 15 May 2017

  7. Short Report

    Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia

    In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly po...

    Jennifer Rakotomamonjy, Molly Brunner, Christoph Jüschke, Keling Zang, Eric J. Huang, Louis F. Reichardt and Anjen Chenn

    Neural Development 2017 12:7

    Published on: 8 May 2017

  8. Research article

    Mutation of Kinesin-6 Kif20b causes defects in cortical neuron polarization and morphogenesis

    How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division ar...

    Katrina C. McNeely, Timothy D. Cupp, Jessica Neville Little, Kerstin M. Janisch, Ayushma Shrestha and Noelle D. Dwyer

    Neural Development 2017 12:5

    Published on: 31 March 2017

  9. Research article

    Lacking of palladin leads to multiple cellular events changes which contribute to NTD

    The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibi...

    Juan Tan, Xue-Jiao Chen, Chun-Ling Shen, Hong-Xin Zhang, Ling-Yun Tang, Shun-Yuan Lu, Wen-Ting Wu, Ying Kuang, Jian Fei and Zhu-Gang Wang

    Neural Development 2017 12:4

    Published on: 24 March 2017

  10. Research article

    The microtubule plus-end-tracking protein TACC3 promotes persistent axon outgrowth and mediates responses to axon guidance signals during development

    Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and t...

    Burcu Erdogan, Garrett M. Cammarata, Eric J. Lee, Benjamin C. Pratt, Andrew F. Francl, Erin L. Rutherford and Laura Anne Lowery

    Neural Development 2017 12:3

    Published on: 15 February 2017

  11. Research Article

    Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain

    Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in ...

    Michelle Ware, Houda Hamdi-Rozé, Julien Le Friec, Véronique David and Valérie Dupé

    Neural Development 2016 11:22

    Published on: 7 December 2016

  12. Research article

    Akirin2 is essential for the formation of the cerebral cortex

    The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cel...

    Peter J. Bosch, Leah C. Fuller, Carolyn M. Sleeth and Joshua A. Weiner

    Neural Development 2016 11:21

    Published on: 21 November 2016

  13. Research article

    Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1

    Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the embryonic hypothalamus. In mice, gliogenesis is a pro...

    Candace M. Marsters, Jessica M. Rosin, Hayley F. Thornton, Shaghayegh Aslanpour, Natasha Klenin, Grey Wilkinson, Carol Schuurmans, Quentin J. Pittman and Deborah M. Kurrasch

    Neural Development 2016 11:20

    Published on: 18 November 2016

  14. Short Report

    Netrin1/DCC signaling promotes neuronal migration in the dorsal spinal cord

    Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during de...

    Harald J. Junge, Andrea R. Yung, Lisa V. Goodrich and Zhe Chen

    Neural Development 2016 11:19

    Published on: 26 October 2016

  15. Research article

    Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling

    Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculo...

    Brielle Bjorke, Farnaz Shoja-Taheri, Minkyung Kim, G. Eric Robinson, Tatiana Fontelonga, Kyung-Tai Kim, Mi-Ryoung Song and Grant S. Mastick

    Neural Development 2016 11:18

    Published on: 22 October 2016

  16. Research article

    Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern

    The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ...

    Emilie Legué, Jackie L. Gottshall, Edouard Jaumouillé, Alberto Roselló-Díez, Wei Shi, Luis Humberto Barraza, Senna Washington, Rachel L. Grant and Alexandra L. Joyner

    Neural Development 2016 11:17

    Published on: 8 September 2016

  17. Research article

    Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons

    Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a...

    William C. Hilinski, Jonathan R. Bostrom, Samantha J. England, José L. Juárez-Morales, Sarah de Jager, Olivier Armant, Jessica Legradi, Uwe Strähle, Brian A. Link and Katharine E. Lewis

    Neural Development 2016 11:16

    Published on: 23 August 2016

  18. Research article

    In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains

    In animals with bilateral symmetry, midline crossing of axons in the developing central nervous system is regulated by Slit ligands and their neuronal Roundabout (Robo) receptors. Multiple structural domains a...

    Marie C. Reichert, Haley E. Brown and Timothy A. Evans

    Neural Development 2016 11:15

    Published on: 18 August 2016

  19. Research article

    Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

    Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ...

    Torrey L. S. Truszkowski, Eric J. James, Mashfiq Hasan, Tyler J. Wishard, Zhenyu Liu, Kara G. Pratt, Hollis T. Cline and Carlos D. Aizenman

    Neural Development 2016 11:14

    Published on: 8 August 2016

  20. Research article

    Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells

    Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe...

    Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques and Richard Blouin

    Neural Development 2016 11:13

    Published on: 28 July 2016

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