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  1. While the transcriptional code governing retinal ganglion cell (RGC) type specification begins to be understood, its interplay with neurotrophic signaling is largely unexplored. In mice, the transcription fact...

    Authors: Vladimir Vladimirovich Muzyka and Tudor Constantin Badea

    Citation: Neural Development 2021 16:5

    Content type: Research article

    Published on:

  3. Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of the nervous system. To generate the diverse morphologies of branched de...

    Authors: Rebecca Shi, Daniel A. Kramer, Baoyu Chen and Kang Shen

    Citation: Neural Development 2021 16:3

    Content type: Research article

    Published on:

  4. The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to ...

    Authors: Gabriela Edwards-Faret, Karina González-Pinto, Arantxa Cebrián-Silla, Johany Peñailillo, José Manuel García-Verdugo and Juan Larraín

    Citation: Neural Development 2021 16:2

    Content type: Research article

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  6. Developing cortical neurons express a tightly choreographed sequence of cytoskeletal and transmembrane proteins to form and strengthen specific synaptic connections during circuit formation. Nectin-3 is a cell...

    Authors: Johanna Tomorsky, Philip R. L. Parker, Chris Q. Doe and Cristopher M. Niell

    Citation: Neural Development 2020 15:13

    Content type: Research article

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  7. In the developing central nervous system, pre-myelinating oligodendrocytes sample candidate nerve axons by extending and retracting process extensions. Some contacts stabilize, leading to the initiation of axo...

    Authors: Heather N. Nelson, Anthony J. Treichel, Erin N. Eggum, Madeline R. Martell, Amanda J. Kaiser, Allie G. Trudel, James R. Gronseth, Samantha T. Maas, Silas Bergen and Jacob H. Hines

    Citation: Neural Development 2020 15:12

    Content type: Research article

    Published on:

  9. Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is protecte...

    Authors: Shiyun Feng, Evanthia Zacharioudaki, Kat Millen and Sarah J. Bray

    Citation: Neural Development 2020 15:10

    Content type: Research article

    Published on:

  10. Spatial patterning specifies neural progenitor identity, with further diversity generated by temporal patterning within individual progenitor lineages. In vertebrates, these mechanisms generate “cardinal class...

    Authors: Austin Seroka, Rita M. Yazejian, Sen-Lin Lai and Chris Q. Doe

    Citation: Neural Development 2020 15:9

    Content type: Research article

    Published on:

  11. Neural tube defects (NTDs) are failure of neural tube closure, which includes multiple central nervous system phenotypes. More than 300 mouse mutant strains exhibits NTDs phenotypes and give us some clues to e...

    Authors: Jizhen Zou, Fang Wang, Xueyan Yang, Hongyan Wang, Lee Niswander, Ting Zhang and Huili Li

    Citation: Neural Development 2020 15:8

    Content type: Research article

    Published on:

  12. Abelson tyrosine kinase (Abl) plays a key role in axon guidance in linking guidance receptors to actin dynamics. The long C-terminal domain (CTD) of Drosophila Abl is important for this role, and previous work...

    Authors: Han Sian Joshua Cheong, Mark Nona, Samantha Barbara Guerra and Mark Francis VanBerkum

    Citation: Neural Development 2020 15:7

    Content type: Research article

    Published on:

  14. The vertebrate retina consists of six major classes of neuronal cells. During development, these cells are generated from a pool of multipotent retinal progenitor cells (RPCs) that express the gene Vsx2. Fate-...

    Authors: Sruti Patoori, Nathalie Jean-Charles, Ariana Gopal, Sacha Sulaiman, Sneha Gopal, Brian Wang, Benjamin Souferi and Mark M. Emerson

    Citation: Neural Development 2020 15:5

    Content type: Research article

    Published on:

  15. Recent studies of synapse form and function highlight the importance of the actin cytoskeleton in regulating multiple aspects of morphogenesis, neurotransmission, and neural plasticity. The conserved actin-ass...

    Authors: Elizabeth M. McNeill, Cheryl Thompson, Brett Berke, Vivian T. Chou, Jannette Rusch, April Duckworth, Jamin DeProto, Alicia Taylor, Julie Gates, Frank Gertler, Haig Keshishian and David Van Vactor

    Citation: Neural Development 2020 15:4

    Content type: Research article

    Published on:

  16. Leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1) regulates stem cell quiescence. As a marker, it identifies stem cells in multiple organs of the mouse. We had detected Lrig1 expression in cultured I...

    Authors: Hyung-song Nam and Mario R. Capecchi

    Citation: Neural Development 2020 15:3

    Content type: Research article

    Published on:

  19. Microglia are increasingly shown to be key players in neuron development and synapse connectivity. However, the underlying mechanisms by which microglia regulate neuron function remain poorly understood in par...

    Authors: Fenge Li, Danye Jiang and Melanie A. Samuel

    Citation: Neural Development 2019 14:12

    Content type: Review

    Published on:

  20. Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an orga...

    Authors: Ines Hahn, André Voelzmann, Yu-Ting Liew, Beatriz Costa-Gomes and Andreas Prokop

    Citation: Neural Development 2019 14:11

    Content type: Review

    Published on:

  24. In the developing neural tube in chicken and mammals, neural stem cells proliferate and differentiate according to a stereotyped spatiotemporal pattern. Several actors have been identified in the control of th...

    Authors: Manon Azaïs, Eric Agius, Stéphane Blanco, Angie Molina, Fabienne Pituello, Jean-Marc Tregan, Anaïs Vallet and Jacques Gautrais

    Citation: Neural Development 2019 14:7

    Content type: Short Report

    Published on:

  25. Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of here...

    Authors: Lauren N. Miterko, Joshua J. White, Tao Lin, Amanda M. Brown, Kevin J. O’Donovan and Roy V. Sillitoe

    Citation: Neural Development 2019 14:6

    Content type: Research article

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  26. Functioning of the adult nervous system depends on the establishment of neural circuits during embryogenesis. In vertebrates, neurons that make up motor circuits form in distinct domains along the dorsoventral...

    Authors: Ozge Yildiz, Gerald B. Downes and Charles G. Sagerström

    Citation: Neural Development 2019 14:5

    Content type: Research article

    Published on:

  27. The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependen...

    Authors: Alexandre Wojcinski, Morgane Morabito, Andrew K. Lawton, Daniel N. Stephen and Alexandra L. Joyner

    Citation: Neural Development 2019 14:4

    Content type: Research article

    Published on:

  29. Mammalian motor circuits display remarkable cellular diversity with hundreds of motor neuron (MN) subtypes innervating hundreds of different muscles. Extensive research on limb muscle-innervating MNs has begun...

    Authors: Catarina Catela, Edgar Correa, Kailong Wen, Jihad Aburas, Laura Croci, G. Giacomo Consalez and Paschalis Kratsios

    Citation: Neural Development 2019 14:2

    Content type: Research article

    Published on:

  30. Waardenburg syndrome (WS) is the consequence of an inherited autosomal dominant mutation which causes the early degeneration of intermediate cells of cochlear stria vascularis (SV) and profound hearing loss. P...

    Authors: Yi Du, Li-li Ren, Qing-qing Jiang, Xing-jian Liu, Fei Ji, Yue Zhang, Shuo-long Yuan, Zi-Ming Wu, Wei-Wei Guo and Shi-Ming Yang

    Citation: Neural Development 2019 14:1

    Content type: Research article

    Published on:

  31. The dorsal lateral geniculate nucleus (dLGN) of the mouse has become a model system for understanding thalamic circuit assembly. While the development of retinal projections to dLGN has been a topic of extensi...

    Authors: Guela Sokhadze, Tania A. Seabrook and William Guido

    Citation: Neural Development 2018 13:27

    Content type: Research article

    Published on:

  32. Cone and rod photoreceptors are two of the primary cell types affected in human retinal disease. Potential strategies to combat these diseases are the use of gene therapy to rescue compromised photoreceptors o...

    Authors: Nathalie Jean-Charles, Diego F. Buenaventura and Mark M. Emerson

    Citation: Neural Development 2018 13:26

    Content type: Research article

    Published on:

  33. Neural stem cells generate all of the neurons and glial cells in the central nervous system, both during development and in the adult to maintain homeostasis. In the Drosophila optic lobe, neuroepithelial cells p...

    Authors: Esteban G. Contreras, Boris Egger, Katrina S. Gold and Andrea H. Brand

    Citation: Neural Development 2018 13:25

    Content type: Research article

    Published on:

  34. Despite conserved developmental processes and organization of the vertebrate central nervous system, only some vertebrates including zebrafish can efficiently regenerate neural damage including after spinal co...

    Authors: Yona Goldshmit, Jean Kitty K. Y. Tang, Ashley L. Siegel, Phong D. Nguyen, Jan Kaslin, Peter D. Currie and Patricia R. Jusuf

    Citation: Neural Development 2018 13:24

    Content type: Research article

    Published on:

  35. Ex vivo, whole-mount explant culture of the rodent retina has proved to be a valuable approach for studying retinal development. In a limited number of recent studies, this method has been coupled to live fluo...

    Authors: Anthony P. Barrasso, Shang Wang, Xuefei Tong, Audrey E. Christiansen, Irina V. Larina and Ross A. Poché

    Citation: Neural Development 2018 13:23

    Content type: Methodology

    Published on:

  36. Proper patterning of dendritic and axonal arbors is a critical step in the formation of functional neuronal circuits. Developing circuits rely on an array of molecular cues to shape arbor morphology, but the u...

    Authors: Rommel A. Santos, Ariel J. C. Fuertes, Ginger Short, Kevin C. Donohue, Hanjuan Shao, Julian Quintanilla, Parinaz Malakzadeh and Susana Cohen-Cory

    Citation: Neural Development 2018 13:22

    Content type: Research article

    Published on:

  37. Homeodomain (HD) transcription factor (TF) NKX2–1 critical for the regional specification of the medial ganglionic eminence (MGE) as well as promoting the GABAergic and cholinergic neuron fates via the inducti...

    Authors: Magnus Sandberg, Leila Taher, Jianxin Hu, Brian L. Black, Alex S. Nord and John L. R. Rubenstein

    Citation: Neural Development 2018 13:21

    Content type: Research article

    Published on:

  39. Glial cell ensheathment of specific components of neuronal circuits is essential for nervous system function. Although ensheathment of axonal segments of differentiated neurons has been investigated, ensheathm...

    Authors: Evan L. Nichols, Lauren A. Green and Cody J. Smith

    Citation: Neural Development 2018 13:19

    Content type: Research article

    Published on:

  41. In the peripheral nervous system (PNS), specialized glial cells called Schwann cells produce myelin, a lipid-rich insulating sheath that surrounds axons and promotes rapid action potential propagation. During ...

    Authors: Rebecca L. Cunningham, Amy L. Herbert, Breanne L. Harty, Sarah D. Ackerman and Kelly R. Monk

    Citation: Neural Development 2018 13:17

    Content type: Research article

    Published on:

  42. In principle, the development of sensory receptive fields in cortex could arise from experience-independent mechanisms that have been acquired through evolution, or through an online analysis of the sensory ex...

    Authors: Arani Roy, Ian K. Christie, Gina M. Escobar, Jason J. Osik, Marjena Popović, Neil J. Ritter, Andrea K. Stacy, Shen Wang, Jozsef Fiser, Paul Miller and Stephen D. Van Hooser

    Citation: Neural Development 2018 13:16

    Content type: Review

    Published on:

  44. About 20–30 distinct Retinal Ganglion Cell (RGC) types transmit visual information from the retina to the brain. The developmental mechanisms by which RGCs are specified are still largely unknown. Brn3a is a m...

    Authors: Vladimir Vladimirovich Muzyka, Matthew Brooks and Tudor Constantin Badea

    Citation: Neural Development 2018 13:15

    Content type: Research article

    Published on:

  45. Previous work aimed at understanding the gene regulatory networks (GRNs) governing caudal hindbrain formation identified morphogens such as Retinoic Acid (RA) and Fibroblast growth factors (FGFs), as well as t...

    Authors: Priyanjali Ghosh, Jennifer M. Maurer and Charles G. Sagerström

    Citation: Neural Development 2018 13:13

    Content type: Research article

    Published on:

  49. Throughout life, neural circuits change their connectivity, especially during development, when neurons frequently extend and retract dendrites and axons, and form and eliminate synapses. In spite of their cha...

    Authors: Nai-Wen Tien and Daniel Kerschensteiner

    Citation: Neural Development 2018 13:9

    Content type: Review

    Published on:

  50. Generation of neurons in the embryonic neocortex is a balanced process of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion of radial glial cells...

    Authors: Olga Chodelkova, Jan Masek, Vladimir Korinek, Zbynek Kozmik and Ondrej Machon

    Citation: Neural Development 2018 13:8

    Content type: Short Report

    Published on:

Editors-in-Chief

Chris Doe
University of Oregon, USA
Julia Kaltschmidt
Stanford University, USA
Beth Stevens
Harvard University, USA

 

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Neural Development

ISSN: 1749-8104