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Research
After axon severing, neurons recover function by reinitiating axon outgrowth. New outgrowth often originates from the remaining axon stump. However, in many mammalian neurons, new axons initiate from a dendrit...
Neural Development 2017 12:15
Published on: 17 August 2017
Short report
Glutamatergic neurons in the cerebral cortex are derived from embryonic neural stem cells known as radial glial progenitors (RGPs). Early RGPs, present at the onset of cortical neurogenesis, are classically th...
Neural Development 2017 12:14
Published on: 16 August 2017
Research article
Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminen...
Neural Development 2017 12:13
Published on: 16 August 2017
Research article
Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural ...
Neural Development 2017 12:12
Published on: 13 July 2017
Research article
The cells of the mesencephalic trigeminal nucleus (MTN) are the proprioceptive sensory neurons that innervate the jaw closing muscles. These cells differentiate close to the two key signalling centres that inf...
Neural Development 2017 12:11
Published on: 21 June 2017
Research article
In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also the...
Neural Development 2017 12:10
Published on: 8 June 2017
Short Report
The corpus callosum forms the major interhemispheric connection in the human brain and is unique to eutherian (or placental) mammals. The developmental events associated with the evolutionary emergence of this...
Neural Development 2017 12:9
Published on: 30 May 2017
Short Report
During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriatel...
Neural Development 2017 12:8
Published on: 15 May 2017
Short Report
In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly po...
Neural Development 2017 12:7
Published on: 8 May 2017
Research article
Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into speciali...
Neural Development 2017 12:6
Published on: 24 April 2017
Research article
How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division ar...
Neural Development 2017 12:5
Published on: 31 March 2017
Research article
The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibi...
Neural Development 2017 12:4
Published on: 24 March 2017
Research article
Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and t...
Neural Development 2017 12:3
Published on: 15 February 2017
Short report
The mammalian primary olfactory system has a spatially-ordered projection in which olfactory sensory neurons (OSNs) located in the dorsomedial (DM) and ventrolateral (VL) region of the olfactory epithelium (OE...
Neural Development 2017 12:2
Published on: 13 February 2017
Research article
Drosophila and mammalian neural progenitors typically generate a diverse family of neurons in a stereotyped order. Neuronal diversity can be generated by the sequential expression of t...
Neural Development 2017 12:1
Published on: 31 January 2017
Research Article
Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in ...
Neural Development 2016 11:22
Published on: 7 December 2016
Research article
The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cel...
Neural Development 2016 11:21
Published on: 21 November 2016
Research article
Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the embryonic hypothalamus. In mice, gliogenesis is a pro...
Neural Development 2016 11:20
Published on: 18 November 2016
Short Report
Newborn neurons often migrate before undergoing final differentiation, extending neurites, and forming synaptic connections. Therefore, neuronal migration is crucial for establishing neural circuitry during de...
Neural Development 2016 11:19
Published on: 26 October 2016
Research article
Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculo...
Neural Development 2016 11:18
Published on: 22 October 2016
Research article
The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ...
Neural Development 2016 11:17
Published on: 8 September 2016
Research article
Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a...
Neural Development 2016 11:16
Published on: 23 August 2016
Research article
In animals with bilateral symmetry, midline crossing of axons in the developing central nervous system is regulated by Slit ligands and their neuronal Roundabout (Robo) receptors. Multiple structural domains a...
Neural Development 2016 11:15
Published on: 18 August 2016
Research article
Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ...
Neural Development 2016 11:14
Published on: 8 August 2016
Research article
Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe...
Neural Development 2016 11:13
Published on: 28 July 2016
