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Table 7 Lmx1b regulates the glutamatergic phenotype of a subset of V0v neurons

From: Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons

 

slc17a6 (glutamatergic)

EGFP (V0v)

co-labeled

48 h

WT

lmx1bb -/-

WT

lmx1bb -/-

WT

lmx1bb -/-

Mean

155

142.2

92.3

93.4

44.3

32.4

SEM

1.54

2.22

2.72

2.58

0.9

1.9

n

6

5

6

5

6

5

p value

<0.001

0.76

<0.001

 

DsRed (glutamatergic)

EGFP (V0v)

co-labeled

7 dpf

WT

lmx1bb -/-

WT

lmx1bb -/-

WT

lmx1bb -/-

Mean

132.6

105.3

100.1

91.3

42.9

21.8

SEM

5.5

5.2

1.4

2.1

4.9

2.7

n

9

12

9

12

9

12

p value

<0.005

0.002

<0.001

  1. Mean number of cells expressing slc17a6, EGFP or both in the spinal cord region adjacent to somites 6–10 in 48 h embryos and the mean number of cells expressing DsRed, EGFP or both in the spinal cord region adjacent to somites 6–10 in 7 dpf embryos. SEM is the standard error of the mean. n is the number of embryos analyzed for each data set. p value is from a student’s paired t-test comparing WT embryos and lmx1bb homozygous mutants. Statistically significant values are indicated in bold
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Neural Development

ISSN: 1749-8104