Fig. 7

Loss of Tcf3/12 in the ventral telencephalon results in increased neuronal markers. At E15.5 and E18.5, Lhx6 expression was examined in the ventral telencephalon to study cells committed to the interneuron fates (A-D). The increased MGE in the dcKOs at E15.5 is occupied with Lhx6 expression (B). At E18.5, the dcKOs continue to show increased Lhx6 expression in the MGE remnant and along path that the interneurons use to migrate to the cortex in the SVZ of the LGE (C-D). Striatal interneurons, determined by Nkx2.1 expression, shows increased numbers in the dcKOs compared to controls at E18.5 (E-F', Quantification G).  Boxes in E and F represent approximate high magnification areas in E’ and F’. Scale bars B = 500 μm (for A-B), D = 500 μm (for C-D), F = 500 μm (for E-F), F’ = 200 μm (for E’-F’). MGE = medial ganglionic eminence, LGE = lateral ganglionic eminence, CTX = Cortex, STM = Striatum