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Fig. 8 | Neural Development

Fig. 8

From: Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation

Fig. 8

Lrig1 knock-out resulted in persistent hyperproliferation in the lateral wall even in old mice. A-C KI-67, ASCL1, or DCX immunoreactivity in 1 year and 3 month-old mice. Scale bar, 100 μm. D-E Graphs of KI-67+ and ASCL1+ cell counts. Mean ± standard deviation. Student’s t test. F-H KI-67, ASCL1, or DCX immunoreactivity in 2 years and 4 month-old mice. Scale bar, 100 μm. I-J Graphs of KI-67+ and ASCL1+ cell counts. Mean ± standard deviation. Student’s t test. K-N KI-67, ASCL1, DCX, or cleaved CASP3 immunoreactivity in 1 year and 8 month-old mice. Scale bar, 100 μm

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Neural Development

ISSN: 1749-8104