Fig. 1
From: Dpr10 and Nocte are required for Drosophila motor axon pathfinding
Dpr10 is required for ISNb pathfinding. (A) Schematic of innervation pattern of the ventral muscle field. The Is motor neuron, vCE, is shown in magenta and Ib neurons are shown in black, teal, and purple. Solid lines indicate the nerve is traveling above muscles while dotted line indicates the nerve is travelling below muscles. (B-D′) Innervation of m13 and m12 with neurons labeled by HRP staining (magenta) and postsynapses labeled with DLG staining (green). Scale bar = 50 μm. (B,B′) Control w1118 animal with the normal innervation pattern (n = 90). (C,C′) dpr10CR animals (light blue) display significant ISNb pathfinding defects (n = 55). Here, m12 is innervated from distal side. (D,D′) dpr10-GAL4 animals (dark green) display significant ISNb pathfinding defects (n = 64). Here, the nerve travels underneath m13 to innervate m12. (E) Quantification of ISNb pathfinding defects of control and dpr10 mutant animals. dpr10CR/dpr10-GAL4 mutants also displayed pathfinding defects, gray bar (n = 48). ****p < 0.0001