Fig. 1
Early competence window is prolonged in corto mutants. A Left, NB7-1 lineage with neural progeny displayed by birth order, clockwise. The neuroblast is at the center and divided into time segments during which each temporal identity factor is expressed. Right, hunchback (hb) is transcriptionally repressed by transient pulse of Svp. Several divisions later, the hb gene relocates to the nuclear lamina, rendering the gene refractory to activation in the neural progeny, closing the early competence window. B NB7-1 lineage early competence assay in representative corto mutant (cortoL1) compared to sibling (heterozygous) control embryo. C Quantification of early competence window (Eve+HA+). Genotypes shown on x-axis. Each datapoint represents the average number of early-born (Eve+HA+) neurons from a single NB7-1 lineage. A minimum of three embryos were quantified per genotype. Data are represented as mean ± SD. P values represent comparisons to wild type. D Schematic summary of corto mutant competence phenotype