Fig. 1
From: Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease
HUWE1 is evolutionarily conserved and broadly expressed in animal nervous systems. a Domain architecture of Huwe1 orthologs from Homo sapiens (Hs), Mus musculus (Mm), Danio rerio (Dr), Drosophila melanogaster (Dm) and Caenorhabditis elegans (Ce). b In situ hybridization of Huwe1 in mouse brain. Note Huwe1 is expressed throughout the brain with high expression in olfactory bulb (OB), cerebral cortex (CTX), hippocampus (HP) and cerebellum (CB). ceel-1 promoter driving GFP expression in C. elegans. eel-1 is widely expressed in the nerve ring and head neurons (left), and ventral nerve cord (right; bars = nerve cord; arrows = motor neuron cell bodies). Schematic denotes locations of images shown and axon bundles of the nerve ring and ventral nerve cord. DUF = conserved Domain of Unknown Function, UBA = Ubiquitin Associated domain, WWE = domain with conserved tryptophan (W) and glutamate (E) residues, UBM = Ubiquitin-Binding Motif (previously known as DUF4414), HECT = Homologous to the E6-AP Carboxyl Terminus (HECT)-type E3 ubiquitin ligase domain. For B, image credit: Allen Institute© 2007 Allen Institute for Brain Science. Allen Mouse Brain Atlas. Available from: https://mouse.brain-map.org/experiment/show/70445293. For C, images reprinted from Cell Reports, Vol. 19, Opperman, Mulcahy, Giles, Risley, Birnbaum, Tulgren, Dawson-Scully, Zhen, Grill, The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development, 822–835, Copyright 2017, with permission from Elsevier