Fig. 3

GAA Model. Same conventions as Fig. 2: evolutions of MoD under the three experimental conditions (a, c, e) and corresponding predictions for progenitors and neurons (b, d, f). Under the GAA model, the evolutions of the two MoD are very different in the CTL condition : G-cells switch to G→ (A,A) MoD early in the process while A-cells keep dividing by self-renewing division A→(A,N) for a long time to compensate the lack of proliferation. Under GoF, both transitions are shifted sooner in time (by 8 hours). Under GoF of mutated CDC25B, only the evolution of A-cells MoD is affected, being delayed by 8 hours. In the three cases, the fitted MoD predict evolutions of progenitors (P=G+A) and neurons (N) in accordance with the data