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Fig. 5 | Neural Development

Fig. 5

From: Monocular enucleation alters retinal waves in the surviving eye

Fig. 5

Effects of removing inter-eye competition on the spatiotemporal properties of retinal waves. a-b) Visualizations of representative waves recorded from the retina of a binocular (a) or and a monocular (b) ferret. Each colored circle represents an RGC active during the period designated on the bottom of (b). Circle size corresponds to RGC firing rate as shown by the legend between (a) and (b). The green cross indicates the center of the wave for each period. c-g Plots showing the difference in size (proportion of electrodes active) (binocular, 0.275 ± 0.158; monocular, 0.224 ± 0.130; mean ± STD; T(977) = 2.58, P = 0.00999, linear mixed-effects model) (c), speed (μm/s) (binocular, 167.67 ± 77.63; monocular, 199.39 ± 83.63; mean ± STD; T(855) = 2.22, P = 0.0267, linear mixed-effects model) (d), spread (proportion of new electrodes active/s) (binocular, 0.060 ± 0.042; monocular, 0.065 ± 0.045; mean ± STD; T(855) = 0.821, P = 0.412, linear mixed-effects model) (e), frequency (waves/min) (binocular, 2.53 ± 1.26; monocular, 2.86 ± 1.64; mean ± STD; T(21) = 1.216, P = 0.237, linear mixed-effects model with log transformation) (f), and duration (s) (binocular, 5.79 ± 3.15; monocular, 5.07 ± 7.60; mean ± STD; T(977) = 5.74, P = 1.233 × 10− 8, linear mixed-effects model with log transformation) (g) of waves recorded from the retinae of binocular and monocular ferrets. The heights of the box plots extend between the 25th and the 75th percentiles of the data. The horizontal bar and cross mark indicate the median and mean, respectively. Outliers are shown as circles and are data points that are 1.5 times higher than or 1.5 times lower than the interquartile range. The box plot whiskers extend to the most extreme data points that are not outliers. Binocular, N = 451 waves, 13 retinae. Monocular, N = 408 waves, 11 retinae. * = P < 0.05, ** = P < 0.01, **** = P < 0.0001

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