Fig. 5
From: Lacking of palladin leads to multiple cellular events changes which contribute to NTD
Cell apoptosis is decreased in Palladin -/- neural tube. A TUNEL assay shows decreased apoptosis in Palladin -/- neural tube at E9.5. B Quantification of TUNEL positive cells/section from the neural tube region. C E9.5 neural tubes are detected for Caspase 3 by IHC. Apoptosis is decreased in Palladin -/- neural tube. The neural fold region in a and b are shown at higher magnification in c and d respectively. D mRNA level of Bcl2 is up-regulated in Palladin -/- embryo brain. White dotted lines outline the neural tube. Error bars indicate SEM; *P < 0.05, ***P < 0.001