Fig. 1
From: Lacking of palladin leads to multiple cellular events changes which contribute to NTD
Palladin -/- embryos exhibit severe cranial neural tube defects at E9.5. A Whole mount embryos at E9.5 in dorsal and ventral view, anterior to the top. Neural tube closure 1 (arrows in the upper panel) forms in both wt and Palladin -/- embryos. Neural tube closure 2 (top arrows in the lower panel) and closure 3 (bottom arrows in the lower panel) fail to occur in Palladin -/- embryos. B Whole mount ISH of E9.5 wt embryos with Palladin isoform 2 probe. Note the main expression of Palladin in the brain region (a). After whole mount ISH, embryos were transected (at the indicated plane in a), Palladin locates predominantly in neural folds (b, c). The boxed region in b is shown at higher magnification in c. Abbreviations: wt-wild type, ISH-in situ hybridization