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Fig. 2 | Neural Development

Fig. 2

From: Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

Fig. 2

Intrinsic properties of tectal neurons are similar between control and FMRP KD tadpoles. a Example traces showing voltage gated inward and outward currents evoked by a series of depolarizing pulses. Voltage steps, 0–90 mV in 10 mV increments, were presented for 150 ms while current was measured, from a holding potential of −60 mV. b Current–voltage relationship of inward sodium (Na) and outward potassium (K) voltage-gated currents. Dotted lines are the K current, solid lines are Na current. c Example spiking traces. Current steps, 10-200pA in 10pA increments were presented for 150 ms while voltage was measured. Voltage injections of 40pA and 180pA shown. d Current vs. spiking relationship. n = 29 per group, At 10pA injection, p = 0.002 and at 20pA injection, p = 0.002 (multiple t-tests by current step, Sidak-Bonferroni multiple comparisons correction). e Maximum number of spikes at a given current injection. n = 29 per group, PMW =0.8376

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Neural Development

ISSN: 1749-8104