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Figure 7 | Neural Development

Figure 7

From: Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits

Figure 7

Isl2-GFP+retinal ganglion cells (RGCs) project to the superior colliculus (SC) and lateral geniculate nucleus (LGN). (A-C) Coronal sections through the SC of an Isl2-GFP mouse in which all RGCs were labeled with fluorescently-conjugated cholera toxin subunit B (CTB-555) (red) reveals dense innervation by Isl2+ RGCs (green). D, dorsal; L, lateral; bar, 250 μm. (D-F) Coronal sections through the lateral geniculate nucleus (LGN) of an Isl2-GFP mouse in which all RGCs were labeled with CTB-555 reveals innervation in the contralateral zone of the dorsal LGN and avoidance of the ventral LGN and intergeniculate leaflet. D, dorsal; L, lateral; bar, 250 μm. (G-J) Coronal sections through the medial tegmental nucleus (MTN) (G), suprachiasmatic nucleus (SCN), olivary pretectal nucleus (OPN) (I) and the pretectum (J) of an Isl2-GFP mouse in which all RGCs were labeled with CTB-555 reveals a lack of innervation of these areas by Isl2-GFP+ RGCs. D, dorsal; M, medial; L, lateral; bar, 100 μm.

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