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Figure 1 | Neural Development

Figure 1

From: RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons

Figure 1

rpm-1 and syd-2 regulate synapse formation in GABAergic motor neurons. (A) Schematic of a DD motor neuron innervating dorsal muscle cells (inspired by Worm Atlas). Green triangles represent presynaptic terminals. P unc-25 SNB-1::GFP (juIs1) was visualized with epifluorescent microscopy for the indicated genotypes. The dorsal cord has gaps (arrow) and aggregated presynaptic terminals (arrowhead) in rpm-1 mutants. (B) Schematic of VD motor neuron innervating ventral muscle cells. Green triangles represent presynaptic terminals. SNB-1::GFP was visualized with epifluorescent microscopy for the indicated genotypes. The ventral cord has gaps (arrow) and aggregated presynaptic terminals (arrowhead) in rpm-1 mutants. In A and B, defects are enhanced in rpm-1; syd-2 double mutants. Analysis was performed on young adults grown at 25°C. DD, dorsal D neuron; VD, ventral D neuron. Scale bar, 10 μm.

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Neural Development

ISSN: 1749-8104