Table 1 Example of expression values for genes selected with an absolute fold change ≥1.3 after Gene Ontology enrichment
From: Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development
Gene symbol | Accession number | Description | Fold change value |
|---|---|---|---|
Notch signalling pathway components | |||
Hes5 | NM_001012695 | Hairy and enhancer of split 5 (Drosophila) | −56.83 |
Hey1 | XM_425926 | Hairy/enhancer-of-split related with YRPW motif 1 | −2.89 |
Nrarp | XM_428951 | Notch-regulated ankyrin repeat protein | −2.02 |
Jag1 | XM_415035 | Jagged 1 | −1.58 |
Numb | NM_204835 | Numb homolog (Drosophila) | −1.49 |
Lfng | NM_204948 | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | −1.46 |
Notch1 | XM_415420 | Notch 1 | −1.31 |
Notch2 | XM_001233595 | Notch 2 | −1.30 |
Aph1a | XM_001233301 | Anterior pharynx defective 1 homolog A (C. elegans) | 1.34 |
Dll1 | NM_204973 | Delta-like 1 (Drosophila) | 2.26 |
Mfng | XM_416278 | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.15 |
Nervous system development Gene Onotology term (upregulated genes) | |||
Neurog1 | NM_204883 | Neurogenin 1 | 8.85 |
Nhlh2 | AF123885 | Nescient helix loop helix 2 | 4.18 |
Nefm | NM_001101730 | Neurofilament, medium polypeptide | 4.05 |
Tagln3 | XM_416634 | Transgelin 3 | 3.69 |
Nhlh1 | NM_204121 | Nescient helix loop helix 1 | 3.47 |
Stmn2 | NM_205181 | Stathmin-like 2 | 2.49 |
Nr5a1 | NM_205077 | Nuclear receptor subfamily 5, group A, member 1 | 1.87 |
Nrg1 | NM_204117 | Neuregulin 1 | 1.77 |
Chga | CR523039 | Chromogranin A (parathyroid secretory protein 1) | 1.74 |
Sim1 | U40058 | Single-minded homolog 1 (Drosophila) | 1.74 |
Bsx | NM_204512 | Brain-specific homeobox | 1.68 |
Ascl1 | NM_204412 | Achaete-scute complex homolog 1 (Drosophila) | 1.67 |
Nr5a2 | NM_205078 | Nuclear receptor subfamily 5, group A, member 2 | 1.59 |
Gap43 | XM_425527 | Growth associated protein 43 | 1.57 |
Neurog2 | NM_204796 | Neurogenin 2 | 1.57 |
Sox14 | NM_204761 | SRY (sex determining region Y)-box 14 | 1.51 |
Robo2 | XM_416674 | Roundabout, axon guidance receptor, homolog 2 (Drosophila) | 1.46 |
Cntn2 | NM_001004395 | Contactin 2 (axonal) | 1.39 |
Slit1 | XM_421715 | Slit homolog 1 (Drosophila) | 1.37 |
Hes6 | BX935736 | Hairy and enhancer of split 6 (Drosophila) | 1.36 |
Bdnf | NM_001031616 | Brain-derived neurotrophic factor | 1.34 |
Foxn4 | NM_001083359 | Forkhead box N4 | 1.31 |
Chrdl1 | NM_204171 | Chordin-like 1 | 1.30 |