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Table 1 Example of expression values for genes selected with an absolute fold change ≥1.3 after Gene Ontology enrichment

From: Novel genes upregulated when NOTCH signalling is disrupted during hypothalamic development

Gene symbol Accession number Description Fold change value
Notch signalling pathway components  
Hes5 NM_001012695 Hairy and enhancer of split 5 (Drosophila) −56.83
Hey1 XM_425926 Hairy/enhancer-of-split related with YRPW motif 1 −2.89
Nrarp XM_428951 Notch-regulated ankyrin repeat protein −2.02
Jag1 XM_415035 Jagged 1 −1.58
Numb NM_204835 Numb homolog (Drosophila) −1.49
Lfng NM_204948 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase −1.46
Notch1 XM_415420 Notch 1 −1.31
Notch2 XM_001233595 Notch 2 −1.30
Aph1a XM_001233301 Anterior pharynx defective 1 homolog A (C. elegans) 1.34
Dll1 NM_204973 Delta-like 1 (Drosophila) 2.26
Mfng XM_416278 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.15
Nervous system development Gene Onotology term (upregulated genes)  
Neurog1 NM_204883 Neurogenin 1 8.85
Nhlh2 AF123885 Nescient helix loop helix 2 4.18
Nefm NM_001101730 Neurofilament, medium polypeptide 4.05
Tagln3 XM_416634 Transgelin 3 3.69
Nhlh1 NM_204121 Nescient helix loop helix 1 3.47
Stmn2 NM_205181 Stathmin-like 2 2.49
Nr5a1 NM_205077 Nuclear receptor subfamily 5, group A, member 1 1.87
Nrg1 NM_204117 Neuregulin 1 1.77
Chga CR523039 Chromogranin A (parathyroid secretory protein 1) 1.74
Sim1 U40058 Single-minded homolog 1 (Drosophila) 1.74
Bsx NM_204512 Brain-specific homeobox 1.68
Ascl1 NM_204412 Achaete-scute complex homolog 1 (Drosophila) 1.67
Nr5a2 NM_205078 Nuclear receptor subfamily 5, group A, member 2 1.59
Gap43 XM_425527 Growth associated protein 43 1.57
Neurog2 NM_204796 Neurogenin 2 1.57
Sox14 NM_204761 SRY (sex determining region Y)-box 14 1.51
Robo2 XM_416674 Roundabout, axon guidance receptor, homolog 2 (Drosophila) 1.46
Cntn2 NM_001004395 Contactin 2 (axonal) 1.39
Slit1 XM_421715 Slit homolog 1 (Drosophila) 1.37
Hes6 BX935736 Hairy and enhancer of split 6 (Drosophila) 1.36
Bdnf NM_001031616 Brain-derived neurotrophic factor 1.34
Foxn4 NM_001083359 Forkhead box N4 1.31
Chrdl1 NM_204171 Chordin-like 1 1.30
  1. HH10 embryos were treated with N-[3.5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) or Dimethyl sulfoxide (DMSO) for 16 hours, and global change in gene expression of the forebrain was compared by microarray analysis. Two Gene Ontology enriched terms have been selected: Notch signalling pathway and Nervous system development. This Gene Ontology term contains 271 enriched genes; 135 were upregulated. Here we have listed the 23 genes for which we have obtained RNA probes. The title and description for each gene are given as well as the accession number and the fold change.