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Figure 5 | Neural Development

Figure 5

From: Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells

Figure 5

Enhanced neurofilament and reduced synaptic protein mRNA levels in the SCG of newborn mice with conditional Dicer 1 inactivation. In newborn mice, DBH ISH signal marks the position of the SCG in (A) control and (G) a mutant animal with homozygous inactivation of floxed Dicer 1 by DBH promoter-driven Cre recombinase (DicercKO). (B, H) Syt1 and (C, I) Snap25 ISH signals are reduced in mutant animals, while (D, J) NF-M and (E, K) NF-L mRNA signals are elevated. (F, L) Different from the neurofilaments, SCG10 mRNA signal is reduced. Scale bar: 100 μm.

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Neural Development

ISSN: 1749-8104