Figure 7
From: NeuroD2 regulates the development of hippocampal mossy fiber synapses
Diagrammatic representation of the proposed role of NeuroD2 in thorny excrescence spine maturation. NeuroD2 is a calcium-activated transcription factor that regulates the transcription of the post-synaptic scaffolding molecule PSD95 amongst other target genes. PSD95 expression downstream of NeuroD2 is part of a pathway regulating the elaboration of TE spine heads during MF synapse development. NeuroD2 also regulates the functional maturation of glutamatergic currents at the MF synapse, an effect that may relate to the role of PSD95 in modulating the AMPAR content of developing synapses.