Figure 5
From: NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrain
Tonic GABA A -mediated currents in migrating RMS neuroblasts and maturing GCs. (A) The photomicrograph shows the typical morphology of a migratory RMS neuroblast recorded at 8 dpi. Current trace shows the spontaneous activity recorded in a migratory neuroblast in the RMS voltage-clamped at -60 mV before and after adding 10 μM gabazine (Gz), revealing a tonic GABAA current. Scale: 5 pA and 5 s. (B) Photomicrograph showing the morphology of a GC recorded at 10 dpi. Example trace of a tonic GABAA-mediated current from GFP+ cells recorded in the GCL. Scale: 10 pA and 20 s. (C) Plot of the average values for GABAA-mediated tonic currents in the two cell types studied. Photomicrograph scale bars are 10 μm in (A) and 20 μm in (B). Error bars indicate standard error of the mean.