Figure 1

Cortical defects are apparent in the brains of Loa/Loa animals, but not in the brains of Loa/+ or wild-type mice. (A) Brain sections stained with DAPI reveal six distinct layers, labeled I to VI, in wild-type and Loa/+ brains, but blurred layer boundaries in the Loa/Loa brains. Scale bar = 200 μm. (B) Wild-type and Loa/Loa brain slices stained with Ctip2, which labels neurons in layers II/III. Brain sections were divided into six equal regions and the corresponding graph shows the mean Ctip2 density within each of these regions for each genotype. Error bars represent the standard deviation. Scale bar = 200 μm. (C) Wild-type and Loa/Loa brain slices stained with Foxp2, which labels neurons in layer VI. Brain sections were divided into six equal regions and the corresponding graph shows the mean Foxp2 density within each of these regions for each genotype. Error bars represent the standard deviation. Scale bar = 200 μm.