Apoptosis occurs both in precursor cells and early differentiating neurons in Rbpj CKO DRG at E11.5. (A-V) Double immunostaining of Caspase3 with Sox10 (A-G), P75 (H-N) and Islet1 (O-V). There are few Caspase+ cells in wild-type (WT) DRG (A,H,O), whereas many Caspase+ cells are present in CKO DRG (D,K,R). Some Caspase+ cells are immunostained with Sox10 (D-G), P75 (K-N) and Islet1(R-V) in CKO DRG. (G,N,V) High magnification views of the areas delineated by white rectangles in (F,M,U), respectively. Arrows indicate the double-labeled cells. Scale bars: 100 μm in (A-F,H-M,O-U); 25 μm in (G,N,V).