Figure 4
From: Nav2 is necessary for cranial nerve development and blood pressure regulation
Cranial nerve IX and X defects are found in homozygous Nav2 hypomorphic mutants. Whole-mount immunostaining for neurofilament protein in (A) a normal Nav2+/+embryo, and in (B, C) Nav2-/-embryos at E11.5. In the Nav2-/-embryo with phenotype 1 (B), the nerve fibers connecting the distal ganglia of IX (white arrowhead) to the proximal ganglia and hindbrain exit point are missing. In the Nav2 mutant showing phenotype 2 (C), the IXth and Xth nerves are fused (brackets). Cranial nerves are indicated in roman numerals: IX, glossopharyngeal; X, vagus; ov, otic vesicle. Scale bar: 200 μm.