Figure 9

Long-term developmental exposure to TNF-α results in increased seizure susceptibility. (A) Tadpoles were exposed to 10 mM of the convulsant agent PTZ in their rearing media and the latency to seizure onset was calculated (see Methods). TNF-α reared tadpoles consistently showed a faster seizure onset time than their control clutchmates. (B) Cumulative probability distribution of seizure onset times for individual tadpoles in both groups. Asterisk indicates p < 0.05. For P-values see Results.