Figure 5
From: Homer regulates calcium signalling in growth cone turning
Homer1 knockdown perturbs dorsal root ganglia growth cone calcium dynamics. (A) Control (closed red circles) morphant growth cones (n = 9) exposed to a brain derived neurotrophic factor (BDNF) micro-gradient show significantly more calcium flux than Homer1 (closed green circles) morphant growth cones (n = 16). (B) Bath application of thapsigargin 2 minutes after establishment of a BDNF micro-gradient elicited a robust rise in intracellular calcium in Homer morphants (hom morph) but failed to elicit any rise in calcium in control morphants (ctrl morph). Error bars indicate standard error of the mean.