Figure 4
From: A synaptic nidogen: Developmental regulation and role of nidogen-2 at the neuromuscular junction
Developmental regulation of nidogens and laminin α chains in synaptic basal lamina (BL). Cross-sections of muscle from P0 (A, D, G, J), P14 (B, E, H, K) and P21 (C, F, I, L) mice, stained for α-bungarotoxin (BTX) and nidogens or laminins. (A-F) While nidogen-1 expression changes little during development (A-C), nidogen-2 is present in both synaptic and extrasynaptic BLs at birth (D) and becomes restricted to synaptic BL postnatally (E, F). (G-L) Laminins α4 (G-I) and α5 (J-L) become restricted to synaptic BL in parallel with nidogen-2. Scale bar is 15 μm for (A, D, G, J) and 10 μm for all other panels.