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Table 1 Postnatal retinal cell genesis as quantified by thymidine birthdating and either immunofluorescent or histological identification of cell fate

From: Temporal order of bipolar cell genesis in the neural retina

  P0 P2 P4 P6
Cell type IF Hist* IF Hist* IF Hist* IF Hist*
Bipolar 2.19 ± 1.45 6.51 3.98 ± 2.66 17.04 12.81 ± 6.16 31.81 16.01 ± 6.31 25.74
   Cone type 1.67 ± 1.15 NA 2.73 ± 1.90 NA 7.96 ± 3.23 NA 8.20 ± 2.97 NA
   Rod type 0.52 ± 0.32 NA 1.21 ± 1.01 NA 4.85 ± 3.35 NA 7.82 ± 3.41 NA
Amacrine NA 9.16 NA 0.05 NA 0.00 NA 0.00
Rod 69.69 ± 12.65 81.67 85.73 ± 4.15 79.51 71.22 ± 5.88 59.54 62.74 ± 8.63 60.59
Muller 0.68 ± 0.26 2.66 0.58 ± 0.43 3.40 2.73 ± 1.08 8.65 4.04 ± 1.97 13.67
  1. Postnatal mice were injected with tritiated thymidine at the developmental time indicated. For the immunofluorescent (IF) methodology, retinae were harvested at P16, dissociated and stained using established cell-type specific markers, namely anti-Chx10 (bipolar cells), Rho4D2 (rod photoreceptors), and anti-glutamine synthetase (Muller cells). *For the histochemical (Hist) estimates all data are based on [19]. Cells born from the central and peripheral sections were summed to thereafter derive a percentage of each cell type