Figure 3

APLP2 is expressed in primary neuronal processes and loss of APLP2 increases neurite length. Primary E18 wild-type neurons were plated and fixed six days later. Neurons were immunostained for (a, c, d) APP and (b, c, d) APLP2. (d, e) E18 primary hippocampal neurons from wild-type (WT) or APLP2 knock out (KO) mice were plated. Three days later, cells were fixed and immunostained for βIII-tubulin and neurite length was measured and quantified. Error bars represent standard error of the mean; *p < 0.05.