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Table 3 Transcripts decreased in the DRG of Brn3a null mice

From: POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

Transcript Symbol Class WT HT KO WT/KO
Limb expression 1 Lix1 Unk 984 923 46 21.4
Vascular endothelial growth factor C Vegfc Dev 55 54 3 16.1
Neural cell adhesion molecule 2 Ncam22 AX 280 212 22 12.9
Runt related 3 Runx3 TX 251 421 22 11.3
Brn3b Pou4f2 TX 613 772 61 10.0
Brn3a Pou4f12 TX 1,107 1,119 115 9.6
Phospholipase A2, group VII Pla2g7 ST 618 438 77 8.1
K+ channel, shaker-related, member 1 Kcna13 NT 438 523 59 7.4
Advillin Avil AX 2,494 1,735 364 6.9
Galanin Gal NT 5,388 4,414 824 6.5
Basonuclin 1 Bnc1 TX 875 740 165 5.3
Insulin-like growth factor 1 Igf13 Dev 820 609 160 5.1
G protein-coupled receptor 64 Gpr642 NT 371 298 72 5.1
Adenylate cyclase activating polypeptide 1, PACAP Adcyap1 NT 283 198 57 5.0
Regulator of G-protein signaling 10 Rgs10 NT 1,793 1,596 362 5.0
Parvalbumin Pvalb ST 403 223 95 4.3
K+ channel, shaker-related, beta member 2 Kcnab2 NT 952 684 238 4.0
Diacylglycerol kinase, eta Dgkh2 ST 1,348 1,230 353 3.8
G protein-coupled receptor 73 Gpr73 NT 336 157 90 3.7
Serine proteinase inhibitor, clade A, member 3G; Spi2A Serpina3g Other 426 346 116 3.7
Copine IV Cpne4 Unk 767 636 216 3.6
PQ loop repeat containing 1 Pqlc1 Unk 911 596 259 3.5
Reticulon 4 receptor-like 2; nogo receptor-like 3 Rtn4rl2 AX 789 694 226 3.5
Spermatogenesis associated glutamate-rich protein 1 Speer1-ps1 Unk 349 307 106 3.3
Pappalysin 2 Pappa2 Other 694 794 225 3.1
Brn3c Pou4f3 TX 394 361 130 3.0
Protein tyrosine phosphatase, receptor type, J Ptprj ST 853 918 284 3.0
Docking protein 4 Dok4 ST 2,014 1655 679 3.0
Selected       
Eph receptor A7 Epha7 AX 206 202 77 2.7
Latexin Lxn NT? 2,948 2,564 1,105 2.7
DRG11 Prrxl1 TX 1,514 1,339 569 2.7
Protein tyrosine phosphatase, non-receptor type 3 Ptpn3 ST 1,638 1,881 623 2.6
GABA-A receptor, subunit alpha 2 Gabra2 NT 62 90 24 2.6
Na+ channel, type VII, alpha Scn7a NT 1,199 1,386 506 2.4
Protein tyrosine phosphatase, receptor type, R Ptprr ST 3,376 3,207 1,467 2.3
Rap1, GTPase-activating protein 1 Rap1ga1 ST 1,721 1,686 749 2.3
LIM domain binding 2 Ldb2 TX 794 492 349 2.3
Anthrax toxin receptor 2 Antxr2 Unk 1,355 1,095 608 2.2
Runt related txn factor 1 Runx1 TX 360 343 162 2.2
Homeobox D1 Hoxd1 TX 852 751 404 2.1
Inhibitor of DNA binding 1 Id1 TX 1,248 1,051 624 2.0
  1. All listed transcripts showed decreased expression (change p > 0.995) in two independent replicates. Complete data appear for all replicated changes above three-fold, and selected data appear for transcripts exhibiting change in the two- to three-fold range. A full data set appears in Additional File 2. Note that Brn3a transcripts are still detected in the Brn3a null genotype, consistent with the detection of the 3'-end of residual non-coding transcripts. AX, neurogenesis/axon growth and guidance; Dev, development; KO, knockout; NT, neurotransmission; ST, signal transduction; SY, synapse formation and function; TX, transcription; Unk, unknown; WT, wild type.