POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

Eng, S Raisa; Dykes, Iain M; Lanier, Jason; Fedtsova, Natalia; Turner, Eric E

doi:10.1186/1749-8104-2-3

Neural Development

Table 3 Transcripts decreased in the DRG of Brn3a null mice

From: POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia

Transcript	Symbol	Class	WT	HT	KO	WT/KO
Limb expression 1	Lix1	Unk	984	923	46	21.4
Vascular endothelial growth factor C	Vegfc	Dev	55	54	3	16.1
Neural cell adhesion molecule 2	Ncam2²	AX	280	212	22	12.9
Runt related 3	Runx3	TX	251	421	22	11.3
Brn3b	Pou4f2	TX	613	772	61	10.0
Brn3a	Pou4f1²	TX	1,107	1,119	115	9.6
Phospholipase A2, group VII	Pla2g7	ST	618	438	77	8.1
K+ channel, shaker-related, member 1	Kcna1³	NT	438	523	59	7.4
Advillin	Avil	AX	2,494	1,735	364	6.9
Galanin	Gal	NT	5,388	4,414	824	6.5
Basonuclin 1	Bnc1	TX	875	740	165	5.3
Insulin-like growth factor 1	Igf1³	Dev	820	609	160	5.1
G protein-coupled receptor 64	Gpr64²	NT	371	298	72	5.1
Adenylate cyclase activating polypeptide 1, PACAP	Adcyap1	NT	283	198	57	5.0
Regulator of G-protein signaling 10	Rgs10	NT	1,793	1,596	362	5.0
Parvalbumin	Pvalb	ST	403	223	95	4.3
K+ channel, shaker-related, beta member 2	Kcnab2	NT	952	684	238	4.0
Diacylglycerol kinase, eta	Dgkh²	ST	1,348	1,230	353	3.8
G protein-coupled receptor 73	Gpr73	NT	336	157	90	3.7
Serine proteinase inhibitor, clade A, member 3G; Spi2A	Serpina3g	Other	426	346	116	3.7
Copine IV	Cpne4	Unk	767	636	216	3.6
PQ loop repeat containing 1	Pqlc1	Unk	911	596	259	3.5
Reticulon 4 receptor-like 2; nogo receptor-like 3	Rtn4rl2	AX	789	694	226	3.5
Spermatogenesis associated glutamate-rich protein 1	Speer1-ps1	Unk	349	307	106	3.3
Pappalysin 2	Pappa2	Other	694	794	225	3.1
Brn3c	Pou4f3	TX	394	361	130	3.0
Protein tyrosine phosphatase, receptor type, J	Ptprj	ST	853	918	284	3.0
Docking protein 4	Dok4	ST	2,014	1655	679	3.0
Selected
Eph receptor A7	Epha7	AX	206	202	77	2.7
Latexin	Lxn	NT?	2,948	2,564	1,105	2.7
DRG11	Prrxl1	TX	1,514	1,339	569	2.7
Protein tyrosine phosphatase, non-receptor type 3	Ptpn3	ST	1,638	1,881	623	2.6
GABA-A receptor, subunit alpha 2	Gabra2	NT	62	90	24	2.6
Na+ channel, type VII, alpha	Scn7a	NT	1,199	1,386	506	2.4
Protein tyrosine phosphatase, receptor type, R	Ptprr	ST	3,376	3,207	1,467	2.3
Rap1, GTPase-activating protein 1	Rap1ga1	ST	1,721	1,686	749	2.3
LIM domain binding 2	Ldb2	TX	794	492	349	2.3
Anthrax toxin receptor 2	Antxr2	Unk	1,355	1,095	608	2.2
Runt related txn factor 1	Runx1	TX	360	343	162	2.2
Homeobox D1	Hoxd1	TX	852	751	404	2.1
Inhibitor of DNA binding 1	Id1	TX	1,248	1,051	624	2.0

All listed transcripts showed decreased expression (change p > 0.995) in two independent replicates. Complete data appear for all replicated changes above three-fold, and selected data appear for transcripts exhibiting change in the two- to three-fold range. A full data set appears in Additional File 2. Note that Brn3a transcripts are still detected in the Brn3a null genotype, consistent with the detection of the 3'-end of residual non-coding transcripts. AX, neurogenesis/axon growth and guidance; Dev, development; KO, knockout; NT, neurotransmission; ST, signal transduction; SY, synapse formation and function; TX, transcription; Unk, unknown; WT, wild type.

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ISSN: 1749-8104

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