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Figure 1 | Neural Development

Figure 1

From: Distinct roles of Hoxa2 and Krox20in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening

Figure 1

Phenotypic traits of Hoxa2-/- mutants at birth: impaired oro-buccal behavior and increased tidal volume. (a) Plethsymographic recordings of wild-type (top), and heterozygous (middle) and homozygous (bottom) Hoxa2 mutant mice at P0. Inspiration is upward. Note that in Hoxa2-/- mice, there is a two-fold increase in tidal volume compared with Hoxa2+/- and wild-type littermates, whereas the frequency is the same (about 110 breaths/minute). (b, c) Individual data relating tidal volume (VT, abscissa) and number (nb) of jaw openings (ordinates) at P0.1. Each symbol corresponds to one animal. Black triangles are for Hoxa2-/- mutants (b, c), open circles represent Hoxa2+/- mutants (c) and open squares correspond to wild-type animals (b). Note that Hoxa2-/- mutants can be separated from other genotypes at P0.1, due to their two-fold increased tidal volume and their reduced number of jaw openings. Broken lines indicate the values used to calculate penetrance of the phenotype (VT, all data inferior to mean – 1 standard deviation; jaw openings, all data superior to mean + 1 standard deviation).

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Neural Development

ISSN: 1749-8104