Figure 6
From: Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe
Model of neuroepithelial to neuroblast transition at the medial edge of the optic lobe. At the medial edge of the optic lobe columnar neuroepithelial cells disassemble adherens junctions and undergo a transition to neuroblasts. Neuroepithelial cells divide symmetrically with horizontal spindle orientation, which results in the expansion of the progenitor pool. Medial neuroblasts divide asymmetrically with vertical spindle orientation and bud off smaller ganglion mother cells (GCMs) towards the presumptive medulla cortex.