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  1. In the visual system of most binocular vertebrates, the axons of retinal ganglion cells (RGCs) diverge at the diencephalic midline and extend to targets on both ipsi- and contralateral sides of the brain. Whil...

    Authors: Paolo Panza, Austen A. Sitko, Hans-Martin Maischein, Iris Koch, Matthias Flötenmeyer, Gavin J. Wright, Kenji Mandai, Carol A. Mason and Christian Söllner

    Citation: Neural Development 2015 10:23

    Content type: Research article

    Published on:

  3. Rac1 is a critical regulator of cytoskeletal dynamics in multiple cell types. In the nervous system, it has been implicated in the control of cell proliferation, neuronal migration, and axon development.

    Authors: Zhong L. Hua, Francesco E. Emiliani and Jeremy Nathans

    Citation: Neural Development 2015 10:21

    Content type: Research article

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  4. N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors and are expressed throughout the central nervous system (CNS). Their activity is required for excitatory synaptic transmi...

    Authors: Caroline Corbel, Israel Hernandez, Bian Wu and Kenneth S. Kosik

    Citation: Neural Development 2015 10:20

    Content type: Short report

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  5. The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been t...

    Authors: Rana N. El-Danaf, Thomas E. Krahe, Emily K. Dilger, Martha E. Bickford, Michael A. Fox and William Guido

    Citation: Neural Development 2015 10:19

    Content type: Research article

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  6. Nonsense mediated mRNA decay (NMD) is an RNA surveillance mechanism that controls RNA stability and ensures the speedy degradation of erroneous and unnecessary transcripts. This mechanism depends on several co...

    Authors: Donghua Zou, Colleen McSweeney, Aswathy Sebastian, Derrick James Reynolds, Fengping Dong, Yijing Zhou, Dazhi Deng, Yonggang Wang, Long Liu, Jun Zhu, Jizhong Zou, Yongsheng Shi, Istvan Albert and Yingwei Mao

    Citation: Neural Development 2015 10:18

    Content type: Research article

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  7. Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate circadian light entrainment and the pupillary light response in adult mice. In early development these cells mediate different processes, in...

    Authors: Timothy J. Sexton, Adam Bleckert, Maxwell H. Turner and Russell N. Van Gelder

    Citation: Neural Development 2015 10:17

    Content type: Research article

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  9. Basic Helix Loop Helix (bHLH) proneural transcription factors are master regulators of neurogenesis that act at multiple stages in this process. We have previously demonstrated that multi-site phosphorylation ...

    Authors: Laura J. A. Hardwick and Anna Philpott

    Citation: Neural Development 2015 10:15

    Content type: Research article

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  10. Netrins are a family of extracellular proteins that function as chemotropic guidance cues for migrating cells and axons during neural development. In the visual system, netrin-1 has been shown to play a key ro...

    Authors: Anastasia N. Nagel, Sonya Marshak, Colleen Manitt, Rommel A. Santos, Marc A. Piercy, Sarah D. Mortero, Nicole J. Shirkey-Son and Susana Cohen-Cory

    Citation: Neural Development 2015 10:14

    Content type: Research article

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  11. Chromatin-modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. The methyl binding domain 3/nucleosome remodelling and deacetyla...

    Authors: Erin Knock, João Pereira, Patrick D Lombard, Andrew Dimond, Donna Leaford, Frederick J Livesey and Brian Hendrich

    Citation: Neural Development 2015 10:13

    Content type: Research article

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  12. Vertebrate retinal development is a complex process, requiring the specification and maintenance of retinal identity, proliferative expansion of retinal progenitor cells (RPCs), and their differentiation into ...

    Authors: Crystal L Sigulinsky, Massiell L German, Amanda M Leung, Anna M Clark, Sanghee Yun and Edward M Levine

    Citation: Neural Development 2015 10:12

    Content type: Research article

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  13. Gene expression patterns are determined by rates of mRNA transcription and decay. While transcription is known to regulate many developmental processes, the role of mRNA decay is less extensively defined. A cr...

    Authors: Dana A Burow, Maxine C Umeh-Garcia, Marie B True, Crystal D Bakhaj, David H Ardell and Michael D Cleary

    Citation: Neural Development 2015 10:11

    Content type: Research article

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  14. Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, which have increased in prevalence in the past two decades. Animal models offer the opportunity to understand the biologi...

    Authors: Laura R Fenlon, Sha Liu, Ilan Gobius, Nyoman D Kurniawan, Skyle Murphy, Randal X Moldrich and Linda J Richards

    Citation: Neural Development 2015 10:10

    Content type: Research article

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  15. During fetal brain development in mammals, newborn neurons undergo cell migration to reach their appropriate positions and form functional circuits. We previously reported that the atypical RhoA GTPase Rnd2 pr...

    Authors: Ivan Enghian Gladwyn-Ng, Shan Shan Li, Zhengdong Qu, John Michael Davis, Linh Ngo, Matilda Haas, Jeffrey Singer and Julian Ik-Tsen Heng

    Citation: Neural Development 2015 10:9

    Content type: Research article

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  16. The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RP...

    Authors: Renée V Hoch, Jeffrey A Clarke and John LR Rubenstein

    Citation: Neural Development 2015 10:8

    Content type: Research article

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  17. Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity. There has been limited analy...

    Authors: Xiumei Wang, Giuseppe Lupo, Rongqiao He, Giuseppina Barsacchi, William A Harris and Ying Liu

    Citation: Neural Development 2015 10:7

    Content type: Research article

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  18. In contrast to mammals, zebrafish successfully regenerate retinal ganglion cell (RGC) axons after optic nerve section (ONS). This difference is explained on the one hand by neurite growth inhibitors in mammals...

    Authors: Cornelia Welte, Sarah Engel and Claudia A O Stuermer

    Citation: Neural Development 2015 10:6

    Content type: Research article

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  19. Axon pathfinding is controlled by guidance cues that elicit specific attractive or repulsive responses in growth cones. It has now become clear that some cues such as Netrin-1 can trigger either attraction or ...

    Authors: Isabelle Dupin, Ludmilla Lokmane, Maxime Dahan, Sonia Garel and Vincent Studer

    Citation: Neural Development 2015 10:5

    Content type: Research article

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  20. The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 9 (2014).

    Authors: Chris Q Doe, William Harris, Kang Shen and Rachel Wong

    Citation: Neural Development 2015 10:4

    Content type: Reviewer acknowledgement

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  21. Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not kn...

    Authors: Michael Piper, Aih Cheun Lee, Francisca PG van Horck, Heather McNeilly, Trina Bo Lu, William A Harris and Christine E Holt

    Citation: Neural Development 2015 10:3

    Content type: Research article

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    The Erratum to this article has been published in Neural Development 2015 10:16

  23. Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had...

    Authors: Paul Charlesworth, Ellese Cotterill, Andrew Morton, Seth GN Grant and Stephen J Eglen

    Citation: Neural Development 2015 10:1

    Content type: Research Article

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  24. Eye development in vertebrates relies on the critical regulation of SOX2 expression. Humans with mutations in SOX2 often suffer from eye defects including anophthalmia (no eye) and microphthalmia (small eye). In ...

    Authors: Whitney E Heavner, Cynthia L Andoniadou and Larysa H Pevny

    Citation: Neural Development 2014 9:27

    Content type: Research article

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  25. During brain development, neurons migrate from germinal zones to their final positions to assemble neural circuits. A unique saltatory cadence involving cyclical organelle movement (e.g., centrosome motility) ...

    Authors: Niraj Trivedi, Joseph S Ramahi, Mahmut Karakaya, Danielle Howell, Ryan A Kerekes and David J Solecki

    Citation: Neural Development 2014 9:26

    Content type: Research article

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  26. Spontaneous retinal activity (SRA) is important during eye-specific segregation within the dorsal lateral geniculate nucleus (dLGN), but the feature(s) of activity critical for retinogeniculate refinement are ...

    Authors: Colenso M Speer, Chao Sun, Lauren C Liets, Ben K Stafford, Barbara Chapman and Hwai-Jong Cheng

    Citation: Neural Development 2014 9:25

    Content type: Research article

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  27. Neural crest cells (NCCs) are a transient embryonic cell type that give rise to a wide spectrum of derivatives, including neurons and glia of the sensory and autonomic nervous system, melanocytes and connectiv...

    Authors: Rachael Lumb, Sophie Wiszniak, Samuela Kabbara, Michaela Scherer, Natasha Harvey and Quenten Schwarz

    Citation: Neural Development 2014 9:24

    Content type: Research article

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  28. Neural stem cell (NSC) differentiation is a complex multistep process that persists in specific regions of the postnatal forebrain and requires tight regulation throughout life. The transcriptional control of ...

    Authors: Bruno Fischer, Kasum Azim, Anahí Hurtado-Chong, Sandra Ramelli, María Fernández and Olivier Raineteau

    Citation: Neural Development 2014 9:23

    Content type: Research article

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  29. Peripheral nerve injuries can severely affect the way that animals perceive signals from the surrounding environment. While damage to peripheral axons generally has a better outcome than injuries to central ne...

    Authors: Maria Laura Ceci, Camila Mardones-Krsulovic, Mario Sánchez, Leonardo E Valdivia and Miguel L Allende

    Citation: Neural Development 2014 9:22

    Content type: Research article

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  30. Neurotrophin-4 (NT-4) and brain derived neurotrophic factor (BDNF) bind to the same receptor, Ntrk2/TrkB, but play distinct roles in the development of the rodent gustatory system. However, the mechanisms unde...

    Authors: Juraj Koudelka, Jacqueline M Horn, Chinnavuth Vatanashevanopakorn and Liliana Minichiello

    Citation: Neural Development 2014 9:21

    Content type: Research article

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  34. Longitudinal axons grow parallel to the embryonic midline to connect distant regions of the central nervous system. Previous studies suggested that repulsive midline signals guide pioneer longitudinal axons by...

    Authors: Minkyung Kim, W Todd Farmer, Brielle Bjorke, Samuel A McMahon, Pierre J Fabre, Frédéric Charron and Grant S Mastick

    Citation: Neural Development 2014 9:17

    Content type: Research article

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  35. Mouse visual thalamus has emerged as a powerful model for understanding the mechanisms underlying neural circuit formation and function. Three distinct nuclei within mouse thalamus receive retinal input, the d...

    Authors: Sarah Hammer, Gabriela L Carrillo, Gubbi Govindaiah, Aboozar Monavarfeshani, Joseph S Bircher, Jianmin Su, William Guido and Michael A Fox

    Citation: Neural Development 2014 9:16

    Content type: Research Article

    Published on:

  36. Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) regulate the survival of gustatory neurons, axon growth and branching, and innervation of taste buds during development. These actions are larg...

    Authors: Da Fei, Tao Huang and Robin F Krimm

    Citation: Neural Development 2014 9:15

    Content type: Research Article

    Published on:

  39. Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during met...

    Authors: Dasfne Lee-Liu, Mauricio Moreno, Leonardo I Almonacid, Víctor S Tapia, Rosana Muñoz, Javier von Marées, Marcia Gaete, Francisco Melo and Juan Larraín

    Citation: Neural Development 2014 9:12

    Content type: Research article

    Published on:

    The Related Article to this article has been published in Nature Protocols 2017 12:BFnprot2016177

  40. Proper binocular vision depends on the routing at the optic chiasm of the correct proportion of retinal ganglion cell (RGC) axons that project to the same (ipsilateral) and opposite (contralateral) side of the...

    Authors: Punita Bhansali, Ilana Rayport, Alexandra Rebsam and Carol Mason

    Citation: Neural Development 2014 9:11

    Content type: Research article

    Published on:

  42. Morphogenesis of the zebrafish neural tube requires the coordinated movement of many cells in both time and space. A good example of this is the movement of the cells in the zebrafish neural plate as they conv...

    Authors: Claudio Araya, Marcel Tawk, Gemma C Girdler, Marta Costa, Carlos Carmona-Fontaine and Jonathan DW Clarke

    Citation: Neural Development 2014 9:9

    Content type: Research article

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  43. As a consequence of gene/genome duplication, the RTN4/Nogo gene has two counterparts in zebrafish: rtn4a and rtn4b. The shared presence of four specific amino acid motifs—M1 to M4—in the N-terminal region of mamm...

    Authors: Alejandro Pinzón-Olejua, Cornelia Welte, Houari Abdesselem, Edward Málaga-Trillo and Claudia AO Stuermer

    Citation: Neural Development 2014 9:8

    Content type: Research article

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  44. Latrophilins (LPHNs) are a small family of neuronal adhesion-GPCRs originally discovered as receptors for the black widow spider toxin α-latrotoxin. Mutations in LPHN3 have recently been identified as risk factor...

    Authors: Matthew L O’Sullivan, Francesca Martini, Sventja von Daake, Davide Comoletti and Anirvan Ghosh

    Citation: Neural Development 2014 9:7

    Content type: Research article

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  45. The genetic programs required for development of the cerebral cortex are under intense investigation. However, non-coding DNA elements that control the expression of developmentally important genes remain poor...

    Authors: Matthew J Eckler, Kathryn A Larkin, William L McKenna, Sol Katzman, Chao Guo, Robin Roque, Axel Visel, John L L Rubenstein and Bin Chen

    Citation: Neural Development 2014 9:6

    Content type: Research article

    Published on:

  46. Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is req...

    Authors: Biliana O Veleva-Rotse, James L Smart, Annette F Baas, Benjamin Edmonds, Zi-ming Zhao, Allyson Brown, Lillian R Klug, Kelly Hansen, Gabrielle Reilly, Alexandria P Gardner, Krishnaveni Subbiah, Eric A Gaucher, Hans Clevers and Anthony P Barnes

    Citation: Neural Development 2014 9:5

    Content type: Research article

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  47. Vertebrates and invertebrates obtain visual motion information by channeling moving visual cues perceived by the retina through specific motion sensitive synaptic relays in the brain. In Drosophila, the series of...

    Authors: Carlos Oliva, Ching-Man Choi, Laura J J Nicolai, Natalia Mora, Natalie De Geest and Bassem A Hassan

    Citation: Neural Development 2014 9:4

    Content type: Research article

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  49. There are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene. This functional specificity is derived from distinct RGC ...

    Authors: Jason W Triplett, Wei Wei, Cristina Gonzalez, Neal T Sweeney, Andrew D Huberman, Marla B Feller and David A Feldheim

    Citation: Neural Development 2014 9:2

    Content type: Research article

    Published on:

  50. The functional integration of the cerebellum into a number of different neural systems is governed by the connection of its output axons. In amniotes, the majority of this output is mediated by an evolutionari...

    Authors: Mary J Green and Richard JT Wingate

    Citation: Neural Development 2014 9:1

    Content type: Research article

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Editors-in-Chief

Chris Doe
University of Oregon, USA
Julia Kaltschmidt
Stanford University, USA
Kang Shen
Stanford University, USA

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Neural Development

ISSN: 1749-8104