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  1. Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe...

    Authors: Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques and Richard Blouin
    Citation: Neural Development 2016 11:13
    Content type: Research article Published on:

  2. Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as ...

    Authors: Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa and Joshua G. Corbin
    Citation: Neural Development 2016 11:12
    Content type: Research article Published on:

  3. Autism Spectrum Disorders (ASD) are the second most common developmental cause of disability in the United States. ASDs are accompanied with substantial economic and emotional cost. The brains of ASD patients ...

    Authors: Christine Pérez, Darrell Sawmiller and Jun Tan
    Citation: Neural Development 2016 11:11
    Content type: Review Published on:

  4. Retinal ganglion cell (RGC) differentiation in vivo is a highly stereotyped process, likely resulting from the interaction of cell type-specific transcription factors and tissue-derived signaling factors. The ...

    Authors: Paola Lepanto, Camila Davison, Gabriela Casanova, Jose L. Badano and Flavio R. Zolessi
    Citation: Neural Development 2016 11:10
    Content type: Research article Published on:

  5. Brain size and patterning are dependent on dosage-sensitive morphogen signaling pathways – yet how these pathways are calibrated remains enigmatic. Recent studies point to a new role for microRNAs in tempering...

    Authors: Giuliana Caronia-Brown, Angela Anderegg and Rajeshwar Awatramani
    Citation: Neural Development 2016 11:9
    Content type: Research article Published on:

  7. The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiat...

    Authors: Ivan Gladwyn-Ng, Lieven Huang, Linh Ngo, Shan Shan Li, Zhengdong Qu, Hannah Kate Vanyai, Hayley Daniella Cullen, John Michael Davis and Julian Ik-Tsen Heng
    Citation: Neural Development 2016 11:7
    Content type: Short Report Published on:

  8. The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 10 (2015).

    Authors: Chris Q. Doe, William Harris, Kang Shen and Rachel Wong
    Citation: Neural Development 2016 11:6
    Content type: Reviewer acknowledgement Published on:

  9. For neurons to function correctly in neuronal circuitry they must utilize appropriate neurotransmitters. However, even though neurotransmitter specificity is one of the most important and defining properties o...

    Authors: José L. Juárez-Morales, Claus J. Schulte, Sofia A. Pezoa, Grace K. Vallejo, William C. Hilinski, Samantha J. England, Sarah de Jager and Katharine E. Lewis
    Citation: Neural Development 2016 11:5
    Content type: Research article Published on:

  10. Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympat...

    Authors: Gerard W. O’Keeffe, Humberto Gutierrez, Laura Howard, Christopher W. Laurie, Catarina Osorio, Núria Gavaldà, Sean L. Wyatt and Alun M. Davies
    Citation: Neural Development 2016 11:4
    Content type: Research article Published on:

  11. The cranial sensory ganglia represent populations of neurons with distinct functions, or sensory modalities. The production of individual ganglia from distinct neurogenic placodes with different developmental ...

    Authors: Cedric Patthey, Harry Clifford, Wilfried Haerty, Chris P. Ponting, Sebastian M. Shimeld and Jo Begbie
    Citation: Neural Development 2016 11:3
    Content type: Research article Published on:

  12. Charcot-Marie-Tooth2b (CMT2b) is an axonal form of a human neurodegenerative disease that preferentially affects sensory neurons. CMT2b is dominantly inherited and is characterized by unusually early onset, pr...

    Authors: Olga Y. Ponomareva, Kevin W. Eliceiri and Mary C. Halloran
    Citation: Neural Development 2016 11:2
    Content type: Research article Published on:

  13. Shaping of the neural tube, the precursor of the brain and spinal cord, involves narrowing and elongation of the neural tissue, concomitantly with other morphogenetic changes that contribue to this process. In...

    Authors: Pradeepa Jayachandran, Valerie N. Olmo, Stephanie P. Sanchez, Rebecca J. McFarland, Eudorah Vital, Jonathan M. Werner, Elim Hong, Neus Sanchez-Alberola, Aleksey Molodstov and Rachel M. Brewster
    Citation: Neural Development 2016 11:1
    Content type: Research article Published on:

  14. Notch signaling has been conserved throughout evolution and plays a fundamental role in various neural developmental processes and the pathogenesis of several human cancers and genetic disorders. However, how ...

    Authors: Yi-Chuan Cheng, Yin-Cheng Huang, Tu-Hsueh Yeh, Hung-Yu Shih, Ching-Yu Lin, Sheng-Jia Lin, Ching-Chi Chiu, Ching-Wen Huang and Yun-Jin Jiang
    Citation: Neural Development 2015 10:28
    Content type: Research article Published on:

  15. In the auditory brainstem, ventral cochlear nucleus (VCN) axons project to the contralateral, but not ipsilateral, medial nucleus of trapezoid body (MNTB), terminating in the calyx of Held. Dorsal VCN neurons,...

    Authors: Mariam L. Abdul-latif, Jesus A. Ayala Salazar, Sonya Marshak, Minhan L. Dinh and Karina S. Cramer
    Citation: Neural Development 2015 10:27
    Content type: Research article Published on:

  16. In mouse embryos, the Pax6 transcription factor is expressed in the progenitors of thalamic neurons but not in thalamic neurons themselves. Its null-mutation causes early mis-patterning of thalamic progenitors...

    Authors: James M. Clegg, Ziwen Li, Michael Molinek, Isabel Martín Caballero, Martine N. Manuel and David J. Price
    Citation: Neural Development 2015 10:26
    Content type: Research Article Published on:

  19. In the visual system of most binocular vertebrates, the axons of retinal ganglion cells (RGCs) diverge at the diencephalic midline and extend to targets on both ipsi- and contralateral sides of the brain. Whil...

    Authors: Paolo Panza, Austen A. Sitko, Hans-Martin Maischein, Iris Koch, Matthias Flötenmeyer, Gavin J. Wright, Kenji Mandai, Carol A. Mason and Christian Söllner
    Citation: Neural Development 2015 10:23
    Content type: Research article Published on:

  21. Rac1 is a critical regulator of cytoskeletal dynamics in multiple cell types. In the nervous system, it has been implicated in the control of cell proliferation, neuronal migration, and axon development.

    Authors: Zhong L. Hua, Francesco E. Emiliani and Jeremy Nathans
    Citation: Neural Development 2015 10:21
    Content type: Research article Published on:

  22. N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors and are expressed throughout the central nervous system (CNS). Their activity is required for excitatory synaptic transmi...

    Authors: Caroline Corbel, Israel Hernandez, Bian Wu and Kenneth S. Kosik
    Citation: Neural Development 2015 10:20
    Content type: Short report Published on:

  23. The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been t...

    Authors: Rana N. El-Danaf, Thomas E. Krahe, Emily K. Dilger, Martha E. Bickford, Michael A. Fox and William Guido
    Citation: Neural Development 2015 10:19
    Content type: Research article Published on:

  24. Nonsense mediated mRNA decay (NMD) is an RNA surveillance mechanism that controls RNA stability and ensures the speedy degradation of erroneous and unnecessary transcripts. This mechanism depends on several co...

    Authors: Donghua Zou, Colleen McSweeney, Aswathy Sebastian, Derrick James Reynolds, Fengping Dong, Yijing Zhou, Dazhi Deng, Yonggang Wang, Long Liu, Jun Zhu, Jizhong Zou, Yongsheng Shi, Istvan Albert and Yingwei Mao
    Citation: Neural Development 2015 10:18
    Content type: Research article Published on:

  25. Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate circadian light entrainment and the pupillary light response in adult mice. In early development these cells mediate different processes, in...

    Authors: Timothy J. Sexton, Adam Bleckert, Maxwell H. Turner and Russell N. Van Gelder
    Citation: Neural Development 2015 10:17
    Content type: Research article Published on:

  27. Basic Helix Loop Helix (bHLH) proneural transcription factors are master regulators of neurogenesis that act at multiple stages in this process. We have previously demonstrated that multi-site phosphorylation ...

    Authors: Laura J. A. Hardwick and Anna Philpott
    Citation: Neural Development 2015 10:15
    Content type: Research article Published on:

  28. Netrins are a family of extracellular proteins that function as chemotropic guidance cues for migrating cells and axons during neural development. In the visual system, netrin-1 has been shown to play a key ro...

    Authors: Anastasia N. Nagel, Sonya Marshak, Colleen Manitt, Rommel A. Santos, Marc A. Piercy, Sarah D. Mortero, Nicole J. Shirkey-Son and Susana Cohen-Cory
    Citation: Neural Development 2015 10:14
    Content type: Research article Published on:

  29. Chromatin-modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. The methyl binding domain 3/nucleosome remodelling and deacetyla...

    Authors: Erin Knock, João Pereira, Patrick D Lombard, Andrew Dimond, Donna Leaford, Frederick J Livesey and Brian Hendrich
    Citation: Neural Development 2015 10:13
    Content type: Research article Published on:

  30. Vertebrate retinal development is a complex process, requiring the specification and maintenance of retinal identity, proliferative expansion of retinal progenitor cells (RPCs), and their differentiation into ...

    Authors: Crystal L Sigulinsky, Massiell L German, Amanda M Leung, Anna M Clark, Sanghee Yun and Edward M Levine
    Citation: Neural Development 2015 10:12
    Content type: Research article Published on:

  31. Gene expression patterns are determined by rates of mRNA transcription and decay. While transcription is known to regulate many developmental processes, the role of mRNA decay is less extensively defined. A cr...

    Authors: Dana A Burow, Maxine C Umeh-Garcia, Marie B True, Crystal D Bakhaj, David H Ardell and Michael D Cleary
    Citation: Neural Development 2015 10:11
    Content type: Research article Published on:

  32. Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, which have increased in prevalence in the past two decades. Animal models offer the opportunity to understand the biologi...

    Authors: Laura R Fenlon, Sha Liu, Ilan Gobius, Nyoman D Kurniawan, Skyle Murphy, Randal X Moldrich and Linda J Richards
    Citation: Neural Development 2015 10:10
    Content type: Research article Published on:

  33. During fetal brain development in mammals, newborn neurons undergo cell migration to reach their appropriate positions and form functional circuits. We previously reported that the atypical RhoA GTPase Rnd2 pr...

    Authors: Ivan Enghian Gladwyn-Ng, Shan Shan Li, Zhengdong Qu, John Michael Davis, Linh Ngo, Matilda Haas, Jeffrey Singer and Julian Ik-Tsen Heng
    Citation: Neural Development 2015 10:9
    Content type: Research article Published on:

  34. The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RP...

    Authors: Renée V Hoch, Jeffrey A Clarke and John LR Rubenstein
    Citation: Neural Development 2015 10:8
    Content type: Research article Published on:

  35. Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity. There has been limited analy...

    Authors: Xiumei Wang, Giuseppe Lupo, Rongqiao He, Giuseppina Barsacchi, William A Harris and Ying Liu
    Citation: Neural Development 2015 10:7
    Content type: Research article Published on:

  36. In contrast to mammals, zebrafish successfully regenerate retinal ganglion cell (RGC) axons after optic nerve section (ONS). This difference is explained on the one hand by neurite growth inhibitors in mammals...

    Authors: Cornelia Welte, Sarah Engel and Claudia A O Stuermer
    Citation: Neural Development 2015 10:6
    Content type: Research article Published on:

  37. Axon pathfinding is controlled by guidance cues that elicit specific attractive or repulsive responses in growth cones. It has now become clear that some cues such as Netrin-1 can trigger either attraction or ...

    Authors: Isabelle Dupin, Ludmilla Lokmane, Maxime Dahan, Sonia Garel and Vincent Studer
    Citation: Neural Development 2015 10:5
    Content type: Research article Published on:

  38. The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 9 (2014).

    Authors: Chris Q Doe, William Harris, Kang Shen and Rachel Wong
    Citation: Neural Development 2015 10:4
    Content type: Reviewer acknowledgement Published on:

  39. Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not kn...

    Authors: Michael Piper, Aih Cheun Lee, Francisca PG van Horck, Heather McNeilly, Trina Bo Lu, William A Harris and Christine E Holt
    Citation: Neural Development 2015 10:3
    Content type: Research article Published on:

    The Erratum to this article has been published in Neural Development 2015 10:16

  41. Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had...

    Authors: Paul Charlesworth, Ellese Cotterill, Andrew Morton, Seth GN Grant and Stephen J Eglen
    Citation: Neural Development 2015 10:1
    Content type: Research Article Published on:

  42. Eye development in vertebrates relies on the critical regulation of SOX2 expression. Humans with mutations in SOX2 often suffer from eye defects including anophthalmia (no eye) and microphthalmia (small eye). In ...

    Authors: Whitney E Heavner, Cynthia L Andoniadou and Larysa H Pevny
    Citation: Neural Development 2014 9:27
    Content type: Research article Published on:

  43. During brain development, neurons migrate from germinal zones to their final positions to assemble neural circuits. A unique saltatory cadence involving cyclical organelle movement (e.g., centrosome motility) ...

    Authors: Niraj Trivedi, Joseph S Ramahi, Mahmut Karakaya, Danielle Howell, Ryan A Kerekes and David J Solecki
    Citation: Neural Development 2014 9:26
    Content type: Research article Published on:

  44. Spontaneous retinal activity (SRA) is important during eye-specific segregation within the dorsal lateral geniculate nucleus (dLGN), but the feature(s) of activity critical for retinogeniculate refinement are ...

    Authors: Colenso M Speer, Chao Sun, Lauren C Liets, Ben K Stafford, Barbara Chapman and Hwai-Jong Cheng
    Citation: Neural Development 2014 9:25
    Content type: Research article Published on:

  45. Neural crest cells (NCCs) are a transient embryonic cell type that give rise to a wide spectrum of derivatives, including neurons and glia of the sensory and autonomic nervous system, melanocytes and connectiv...

    Authors: Rachael Lumb, Sophie Wiszniak, Samuela Kabbara, Michaela Scherer, Natasha Harvey and Quenten Schwarz
    Citation: Neural Development 2014 9:24
    Content type: Research article Published on:

  46. Neural stem cell (NSC) differentiation is a complex multistep process that persists in specific regions of the postnatal forebrain and requires tight regulation throughout life. The transcriptional control of ...

    Authors: Bruno Fischer, Kasum Azim, Anahí Hurtado-Chong, Sandra Ramelli, María Fernández and Olivier Raineteau
    Citation: Neural Development 2014 9:23
    Content type: Research article Published on:

  47. Peripheral nerve injuries can severely affect the way that animals perceive signals from the surrounding environment. While damage to peripheral axons generally has a better outcome than injuries to central ne...

    Authors: Maria Laura Ceci, Camila Mardones-Krsulovic, Mario Sánchez, Leonardo E Valdivia and Miguel L Allende
    Citation: Neural Development 2014 9:22
    Content type: Research article Published on:

  48. Neurotrophin-4 (NT-4) and brain derived neurotrophic factor (BDNF) bind to the same receptor, Ntrk2/TrkB, but play distinct roles in the development of the rodent gustatory system. However, the mechanisms unde...

    Authors: Juraj Koudelka, Jacqueline M Horn, Chinnavuth Vatanashevanopakorn and Liliana Minichiello
    Citation: Neural Development 2014 9:21
    Content type: Research article Published on:

Editors-in-Chief

Chris Doe
University of Oregon, USA
Julia Kaltschmidt
Stanford University, USA
Beth Stevens
Harvard University, USA

 

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Neural Development

ISSN: 1749-8104