Citation: Neural Development 2015 10:22
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Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems
Rac1 is a critical regulator of cytoskeletal dynamics in multiple cell types. In the nervous system, it has been implicated in the control of cell proliferation, neuronal migration, and axon development.
Citation: Neural Development 2015 10:21
N-methyl-D-aspartate receptors (NMDARs) are a subtype of ionotropic glutamate receptors and are expressed throughout the central nervous system (CNS). Their activity is required for excitatory synaptic transmi...
Citation: Neural Development 2015 10:20
Developmental remodeling of relay cells in the dorsal lateral geniculate nucleus in the absence of retinal input
The dorsal lateral geniculate nucleus (dLGN) of the mouse has been an important experimental model for understanding thalamic circuit development. The developmental remodeling of retinal projections has been t...
Citation: Neural Development 2015 10:19
Nonsense mediated mRNA decay (NMD) is an RNA surveillance mechanism that controls RNA stability and ensures the speedy degradation of erroneous and unnecessary transcripts. This mechanism depends on several co...
Citation: Neural Development 2015 10:18
Type I intrinsically photosensitive retinal ganglion cells of early post-natal development correspond to the M4 subtype
Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate circadian light entrainment and the pupillary light response in adult mice. In early development these cells mediate different processes, in...
Citation: Neural Development 2015 10:17
Citation: Neural Development 2015 10:16
Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins
Basic Helix Loop Helix (bHLH) proneural transcription factors are master regulators of neurogenesis that act at multiple stages in this process. We have previously demonstrated that multi-site phosphorylation ...
Citation: Neural Development 2015 10:15
Netrins are a family of extracellular proteins that function as chemotropic guidance cues for migrating cells and axons during neural development. In the visual system, netrin-1 has been shown to play a key ro...
Citation: Neural Development 2015 10:14
The methyl binding domain 3/nucleosome remodelling and deacetylase complex regulates neural cell fate determination and terminal differentiation in the cerebral cortex
Chromatin-modifying complexes have key roles in regulating various aspects of neural stem cell biology, including self-renewal and neurogenesis. The methyl binding domain 3/nucleosome remodelling and deacetyla...
Citation: Neural Development 2015 10:13
Vertebrate retinal development is a complex process, requiring the specification and maintenance of retinal identity, proliferative expansion of retinal progenitor cells (RPCs), and their differentiation into ...
Citation: Neural Development 2015 10:12
Gene expression patterns are determined by rates of mRNA transcription and decay. While transcription is known to regulate many developmental processes, the role of mRNA decay is less extensively defined. A cr...
Citation: Neural Development 2015 10:11
Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder
Autism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, which have increased in prevalence in the past two decades. Animal models offer the opportunity to understand the biologi...
Citation: Neural Development 2015 10:10
Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex
During fetal brain development in mammals, newborn neurons undergo cell migration to reach their appropriate positions and form functional circuits. We previously reported that the atypical RhoA GTPase Rnd2 pr...
Citation: Neural Development 2015 10:9
Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center
The rostral patterning center (RPC) secretes multiple fibroblast growth factors (Fgfs) essential for telencephalon growth and patterning. Fgf expression patterns suggest that they mark functionally distinct RP...
Citation: Neural Development 2015 10:8
Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling
Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity. There has been limited analy...
Citation: Neural Development 2015 10:7
Upregulation of the zebrafish Nogo-A homologue, Rtn4b, in retinal ganglion cells is functionally involved in axon regeneration
In contrast to mammals, zebrafish successfully regenerate retinal ganglion cell (RGC) axons after optic nerve section (ONS). This difference is explained on the one hand by neurite growth inhibitors in mammals...
Citation: Neural Development 2015 10:6
Axon pathfinding is controlled by guidance cues that elicit specific attractive or repulsive responses in growth cones. It has now become clear that some cues such as Netrin-1 can trigger either attraction or ...
Citation: Neural Development 2015 10:5
The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 9 (2014).
Citation: Neural Development 2015 10:4
Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones
Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not kn...
Citation: Neural Development 2015 10:3
Identifying the mechanisms by which cells remain irreversibly committed to their fates is a critical step toward understanding and being able to manipulate development and homeostasis. Polycomb group (PcG) pro...
Citation: Neural Development 2015 10:2
Quantitative differences in developmental profiles of spontaneous activity in cortical and hippocampal cultures
Neural circuits can spontaneously generate complex spatiotemporal firing patterns during development. This spontaneous activity is thought to help guide development of the nervous system. In this study, we had...
Citation: Neural Development 2015 10:1
Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling
Eye development in vertebrates relies on the critical regulation of SOX2 expression. Humans with mutations in SOX2 often suffer from eye defects including anophthalmia (no eye) and microphthalmia (small eye). In ...
Citation: Neural Development 2014 9:27
Leading-process actomyosin coordinates organelle positioning and adhesion receptor dynamics in radially migrating cerebellar granule neurons
During brain development, neurons migrate from germinal zones to their final positions to assemble neural circuits. A unique saltatory cadence involving cyclical organelle movement (e.g., centrosome motility) ...
Citation: Neural Development 2014 9:26
Eye-specific retinogeniculate segregation proceeds normally following disruption of patterned spontaneous retinal activity
Spontaneous retinal activity (SRA) is important during eye-specific segregation within the dorsal lateral geniculate nucleus (dLGN), but the feature(s) of activity critical for retinogeniculate refinement are ...
Citation: Neural Development 2014 9:25
Neural crest cells (NCCs) are a transient embryonic cell type that give rise to a wide spectrum of derivatives, including neurons and glia of the sensory and autonomic nervous system, melanocytes and connectiv...
Citation: Neural Development 2014 9:24
E-proteins orchestrate the progression of neural stem cell differentiation in the postnatal forebrain
Neural stem cell (NSC) differentiation is a complex multistep process that persists in specific regions of the postnatal forebrain and requires tight regulation throughout life. The transcriptional control of ...
Citation: Neural Development 2014 9:23
Peripheral nerve injuries can severely affect the way that animals perceive signals from the surrounding environment. While damage to peripheral axons generally has a better outcome than injuries to central ne...
Citation: Neural Development 2014 9:22
Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system
Neurotrophin-4 (NT-4) and brain derived neurotrophic factor (BDNF) bind to the same receptor, Ntrk2/TrkB, but play distinct roles in the development of the rodent gustatory system. However, the mechanisms unde...
Citation: Neural Development 2014 9:21
The conserved habenular nuclei function as a relay system connecting the forebrain with the brain stem. They play crucial roles in various cognitive behaviors by modulating cholinergic, dopaminergic and seroto...
Citation: Neural Development 2014 9:20
In the spinal cord, stereotypic patterns of transcription factor expression uniquely identify neuronal subtypes. These transcription factors function combinatorially to regulate gene expression. Consequently, ...
Citation: Neural Development 2014 9:19
During early brain development, the organisation of neural progenitors into a neuroepithelial sheet maintains tissue integrity during growth. Neuroepithelial cohesion and patterning is essential for orderly pr...
Citation: Neural Development 2014 9:18
Pioneer midbrain longitudinal axons navigate using a balance of Netrin attraction and Slit repulsion
Longitudinal axons grow parallel to the embryonic midline to connect distant regions of the central nervous system. Previous studies suggested that repulsive midline signals guide pioneer longitudinal axons by...
Citation: Neural Development 2014 9:17
Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus
Mouse visual thalamus has emerged as a powerful model for understanding the mechanisms underlying neural circuit formation and function. Three distinct nuclei within mouse thalamus receive retinal input, the d...
Citation: Neural Development 2014 9:16
The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development
Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) regulate the survival of gustatory neurons, axon growth and branching, and innervation of taste buds during development. These actions are larg...
Citation: Neural Development 2014 9:15
The thalamus is often defined as the ‘gateway to consciousness’, a feature that is supported by the specific connectivity and electrophysiological properties of its neurons. Inhibitory GABAergic neurons are re...
Citation: Neural Development 2014 9:14
Synapse formation occurs when synaptogenic signals trigger coordinated development of pre and postsynaptic structures. One of the best-characterized synaptogenic signals is trans-synaptic adhesion. However, it...
Citation: Neural Development 2014 9:13
Genome-wide expression profile of the response to spinal cord injury in Xenopus laevis reveals extensive differences between regenerative and non-regenerative stages
Xenopus laevis has regenerative and non-regenerative stages. As a tadpole, it is fully capable of functional recovery after a spinal cord injury, while its juvenile form (froglet) loses this capability during met...
Citation: Neural Development 2014 9:12
Delayed neurogenesis leads to altered specification of ventrotemporal retinal ganglion cells in albino mice
Proper binocular vision depends on the routing at the optic chiasm of the correct proportion of retinal ganglion cell (RGC) axons that project to the same (ipsilateral) and opposite (contralateral) side of the...
Citation: Neural Development 2014 9:11
RPM-1 is localized to distinct subcellular compartments and regulates axon length in GABAergic motor neurons
The PAM/Highwire/RPM-1 (PHR) proteins are conserved signaling proteins that regulate axon length and synapse formation during development. Loss of function in Caenorhabditis elegans rpm-1 results in axon terminat...
Citation: Neural Development 2014 9:10
Morphogenesis of the zebrafish neural tube requires the coordinated movement of many cells in both time and space. A good example of this is the movement of the cells in the zebrafish neural plate as they conv...
Citation: Neural Development 2014 9:9
As a consequence of gene/genome duplication, the RTN4/Nogo gene has two counterparts in zebrafish: rtn4a and rtn4b. The shared presence of four specific amino acid motifs—M1 to M4—in the N-terminal region of mamm...
Citation: Neural Development 2014 9:8
LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5
Latrophilins (LPHNs) are a small family of neuronal adhesion-GPCRs originally discovered as receptors for the black widow spider toxin α-latrotoxin. Mutations in LPHN3 have recently been identified as risk factor...
Citation: Neural Development 2014 9:7
The genetic programs required for development of the cerebral cortex are under intense investigation. However, non-coding DNA elements that control the expression of developmentally important genes remain poor...
Citation: Neural Development 2014 9:6
Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is req...
Citation: Neural Development 2014 9:5
Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells
Vertebrates and invertebrates obtain visual motion information by channeling moving visual cues perceived by the retina through specific motion sensitive synaptic relays in the brain. In Drosophila, the series of...
Citation: Neural Development 2014 9:4
Light information is sorted by neuronal circuits to generate image-forming (IF) (interpretation and tracking of visual objects and patterns) and non-image-forming (NIF) tasks. Among the NIF tasks, photic entra...
Citation: Neural Development 2014 9:3
Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits
There are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene. This functional specificity is derived from distinct RGC ...
Citation: Neural Development 2014 9:2
The functional integration of the cerebellum into a number of different neural systems is governed by the connection of its output axons. In amniotes, the majority of this output is mediated by an evolutionari...
Citation: Neural Development 2014 9:1
The generation of diverse neuronal types and subtypes from multipotent progenitors during development is crucial for assembling functional neural circuits in the adult central nervous system. It is well known ...
Citation: Neural Development 2013 8:25
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