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  1. About 20–30 distinct Retinal Ganglion Cell (RGC) types transmit visual information from the retina to the brain. The developmental mechanisms by which RGCs are specified are still largely unknown. Brn3a is a m...

    Authors: Vladimir Vladimirovich Muzyka, Matthew Brooks and Tudor Constantin Badea
    Citation: Neural Development 2018 13:15
    Content type: Research article Published on:

  2. Previous work aimed at understanding the gene regulatory networks (GRNs) governing caudal hindbrain formation identified morphogens such as Retinoic Acid (RA) and Fibroblast growth factors (FGFs), as well as t...

    Authors: Priyanjali Ghosh, Jennifer M. Maurer and Charles G. Sagerström
    Citation: Neural Development 2018 13:13
    Content type: Research article Published on:

  6. Throughout life, neural circuits change their connectivity, especially during development, when neurons frequently extend and retract dendrites and axons, and form and eliminate synapses. In spite of their cha...

    Authors: Nai-Wen Tien and Daniel Kerschensteiner
    Citation: Neural Development 2018 13:9
    Content type: Review Published on:

  7. Generation of neurons in the embryonic neocortex is a balanced process of proliferation and differentiation of neuronal progenitor cells. Canonical Wnt signalling is crucial for expansion of radial glial cells...

    Authors: Olga Chodelkova, Jan Masek, Vladimir Korinek, Zbynek Kozmik and Ondrej Machon
    Citation: Neural Development 2018 13:8
    Content type: Short Report Published on:

  9. More than 30 years of studies into Drosophila melanogaster neurogenesis have revealed fundamental insights into our understanding of axon guidance mechanisms, neural differentiation, and early cell fate decisions...

    Authors: Matthew Q. Clark, Aref Arzan Zarin, Arnaldo Carreira-Rosario and Chris Q. Doe
    Citation: Neural Development 2018 13:6
    Content type: Review Published on:

  10. Brain function requires precise neural circuit assembly during development. Establishing a functional circuit involves multiple coordinated steps ranging from neural cell fate specification to proper matching ...

    Authors: Hongjie Li, S. Andrew Shuster, Jiefu Li and Liqun Luo
    Citation: Neural Development 2018 13:5
    Content type: Review Published on:

  11. Activity in neurons drives afferent competition that is critical for the refinement of nascent neural circuits. In ferrets, when an eye is lost in early development, surviving retinogeniculate afferents from t...

    Authors: Samuel Wilson Failor, Arash Ng and Hwai-Jong Cheng
    Citation: Neural Development 2018 13:4
    Content type: Research article Published on:

  12. Most oligodendrocytes of the spinal cord originate from ventral progenitor cells of the pMN domain, characterized by expression of the transcription factor Olig2. A minority of oligodendrocytes is also recogni...

    Authors: Marie-Amélie Farreny, Eric Agius, Sophie Bel-Vialar, Nathalie Escalas, Nagham Khouri-Farah, Chadi Soukkarieh, Cathy Danesin, Fabienne Pituello, Philippe Cochard and Cathy Soula
    Citation: Neural Development 2018 13:3
    Content type: Research article Published on:

  13. Radial glial stem cells within the developing nervous system generate a variety of post-mitotic cells, including neurons and glial cells, as well as the specialised multi-ciliated cells that line the walls of ...

    Authors: Diana Vidovic, Raul Ayala Davila, Richard M. Gronostajski, Tracey J. Harvey and Michael Piper
    Citation: Neural Development 2018 13:2
    Content type: Short Report Published on:

  14. After publication of the original article [1] it was realised that there were errors in figures 2a,b,f,g, which arose as a result of preparing figures from data collected and analysed at the same time as the w...

    Authors: Olivier Clément, Isabel Anne Hemming, Ivan Enghian Gladwyn-Ng, Zhengdong Qu, Shan Shan Li, Michael Piper and Julian Ik-Tsen Heng
    Citation: Neural Development 2018 13:1
    Content type: Correction Published on:

    The original article was published in Neural Development 2017 12:8

  15. The multiplex, lattice mosaic of cone photoreceptors in the adult fish retina is a compelling example of a highly ordered epithelial cell pattern, with single cell width rows and columns of cones and precisely...

    Authors: Mikiko Nagashima, Jeremy Hadidjojo, Linda K. Barthel, David K. Lubensky and Pamela A. Raymond
    Citation: Neural Development 2017 12:20
    Content type: Research article Published on:

  16. Patterning of the telencephalic neuroepithelium is a tightly regulated process controlled by transcription factors and signalling molecules. The cortical primordium is flanked by two signalling centres, the he...

    Authors: Geeta Godbole, Achira Roy, Ashwin S. Shetty and Shubha Tole
    Citation: Neural Development 2017 12:19
    Content type: Short report Published on:

  17. The axons of Olfactory Sensory Neurons (OSNs) project to reproducible target locations within the Olfactory Bulb (OB), converting odorant experience into a spatial map of neural activity. We characterized the ...

    Authors: Xin Shao, Vanisha Lakhina, Puneet Dang, Ryan P. Cheng, Christina L. Marcaccio and Jonathan A. Raper
    Citation: Neural Development 2017 12:18
    Content type: Research Published on:

  18. Cyclin-dependent kinase (CDK) inhibitors play an important role in regulating cell cycle progression, cell cycle exit and cell differentiation. p27KIP1 (p27), one of the major CDK inhibitors in the retina, has be...

    Authors: Mariko Ogawa, Fuminori Saitoh, Norihiro Sudou, Fumi Sato and Hiroki Fujieda
    Citation: Neural Development 2017 12:17
    Content type: Research article Published on:

  19. Amacrine interneurons that modulate synaptic plasticity between bipolar and ganglion cells constitute the most diverse cell type in the retina. Most are inhibitory neurons using either GABA or glycine as neuro...

    Authors: Nathalie Bessodes, Karine Parain, Odile Bronchain, Eric J. Bellefroid and Muriel Perron
    Citation: Neural Development 2017 12:16
    Content type: Research article Published on:

  20. After axon severing, neurons recover function by reinitiating axon outgrowth. New outgrowth often originates from the remaining axon stump. However, in many mammalian neurons, new axons initiate from a dendrit...

    Authors: Kavitha S. Rao and Melissa M. Rolls
    Citation: Neural Development 2017 12:15
    Content type: Research Published on:

  21. Glutamatergic neurons in the cerebral cortex are derived from embryonic neural stem cells known as radial glial progenitors (RGPs). Early RGPs, present at the onset of cortical neurogenesis, are classically th...

    Authors: E. S. Kaplan, K. A. Ramos-Laguna, A. B. Mihalas, R. A. M. Daza and R. F. Hevner
    Citation: Neural Development 2017 12:14
    Content type: Short report Published on:

  22. Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminen...

    Authors: Shenyue Qin, Stephanie M. Ware, Ronald R. Waclaw and Kenneth Campbell
    Citation: Neural Development 2017 12:13
    Content type: Research article Published on:

  23. Regeneration of neurons in the central nervous system is poor in humans. In other vertebrates neural regeneration does occur efficiently and involves reactivation of developmental processes. Within the neural ...

    Authors: Jeremy Ng Chi Kei, Peter David Currie and Patricia Regina Jusuf
    Citation: Neural Development 2017 12:12
    Content type: Research article Published on:

  24. The cells of the mesencephalic trigeminal nucleus (MTN) are the proprioceptive sensory neurons that innervate the jaw closing muscles. These cells differentiate close to the two key signalling centres that inf...

    Authors: Marcela Lipovsek, Julia Ledderose, Thomas Butts, Tanguy Lafont, Clemens Kiecker, Andrea Wizenmann and Anthony Graham
    Citation: Neural Development 2017 12:11
    Content type: Research article Published on:

  25. In the vertebrate spinal cord, motor neurons (MN) are generated in stereotypical numbers from a pool of dedicated progenitors (pMN) whose number depends on signals that control their specification but also the...

    Authors: Julien Laussu, Christophe Audouard, Anthony Kischel, Poincyane Assis-Nascimento, Nathalie Escalas, Daniel J. Liebl, Cathy Soula and Alice Davy
    Citation: Neural Development 2017 12:10
    Content type: Research article Published on:

  26. The corpus callosum forms the major interhemispheric connection in the human brain and is unique to eutherian (or placental) mammals. The developmental events associated with the evolutionary emergence of this...

    Authors: Ilan Gobius, Rodrigo Suárez, Laura Morcom, Annalisa Paolino, Timothy J. Edwards, Peter Kozulin and Linda J. Richards
    Citation: Neural Development 2017 12:9
    Content type: Short Report Published on:

  27. During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriatel...

    Authors: Olivier Clément, Isabel Anne Hemming, Ivan Enghian Gladwyn-Ng, Zhengdong Qu, Shan Shan Li, Michael Piper and Julian Ik-Tsen Heng
    Citation: Neural Development 2017 12:8
    Content type: Short Report Published on:

    The Correction to this article has been published in Neural Development 2018 13:1

  28. In developing tissues, cell polarity and tissue architecture play essential roles in the regulation of proliferation and differentiation. During cerebral cortical development, adherens junctions link highly po...

    Authors: Jennifer Rakotomamonjy, Molly Brunner, Christoph Jüschke, Keling Zang, Eric J. Huang, Louis F. Reichardt and Anjen Chenn
    Citation: Neural Development 2017 12:7
    Content type: Short Report Published on:

  29. Sensory processing relies on projections from the thalamus to the neocortex being established during development. Information from different sensory modalities reaching the thalamus is segregated into speciali...

    Authors: Manuela D. Mitsogiannis, Graham E. Little and Kevin J. Mitchell
    Citation: Neural Development 2017 12:6
    Content type: Research article Published on:

  30. How neurons change their cytoskeleton to adopt their complex polarized morphology is still not understood. Growing evidence suggests that proteins that help build microtubule structures during cell division ar...

    Authors: Katrina C. McNeely, Timothy D. Cupp, Jessica Neville Little, Kerstin M. Janisch, Ayushma Shrestha and Noelle D. Dwyer
    Citation: Neural Development 2017 12:5
    Content type: Research article Published on:

  31. The actin cytoskeleton-associated protein palladin plays an important role in cell motility, morphogenesis and adhesion. In mice, Palladin deficient embryos are lethal before embryonic day (E) 15.5, and exhibi...

    Authors: Juan Tan, Xue-Jiao Chen, Chun-Ling Shen, Hong-Xin Zhang, Ling-Yun Tang, Shun-Yuan Lu, Wen-Ting Wu, Ying Kuang, Jian Fei and Zhu-Gang Wang
    Citation: Neural Development 2017 12:4
    Content type: Research article Published on:

  32. Formation of precise neuronal connections requires proper axon guidance. Microtubules (MTs) of the growth cone provide a critical driving force during navigation of the growing ends of axons. Pioneer MTs and t...

    Authors: Burcu Erdogan, Garrett M. Cammarata, Eric J. Lee, Benjamin C. Pratt, Andrew F. Francl, Erin L. Rutherford and Laura Anne Lowery
    Citation: Neural Development 2017 12:3
    Content type: Research article Published on:

  33. The mammalian primary olfactory system has a spatially-ordered projection in which olfactory sensory neurons (OSNs) located in the dorsomedial (DM) and ventrolateral (VL) region of the olfactory epithelium (OE...

    Authors: Eerdunfu, Naoki Ihara, Bao Ligao, Yuji Ikegaya and Haruki Takeuchi
    Citation: Neural Development 2017 12:2
    Content type: Short report Published on:

  34. Drosophila and mammalian neural progenitors typically generate a diverse family of neurons in a stereotyped order. Neuronal diversity can be generated by the sequential expression of t...

    Authors: Keiko Hirono, Minoree Kohwi, Matt Q. Clark, Ellie S. Heckscher and Chris Q. Doe
    Citation: Neural Development 2017 12:1
    Content type: Research article Published on:

  35. Neurons arise in very specific regions of the neural tube, controlled by components of the Notch signalling pathway, proneural genes, and other bHLH transcription factors. How these specific neuronal areas in ...

    Authors: Michelle Ware, Houda Hamdi-Rozé, Julien Le Friec, Véronique David and Valérie Dupé
    Citation: Neural Development 2016 11:22
    Content type: Research Article Published on:

  36. The proper spatial and temporal regulation of dorsal telencephalic progenitor behavior is a prerequisite for the formation of the highly-organized, six-layered cerebral cortex. Premature differentiation of cel...

    Authors: Peter J. Bosch, Leah C. Fuller, Carolyn M. Sleeth and Joshua A. Weiner
    Citation: Neural Development 2016 11:21
    Content type: Research article Published on:

  37. Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the embryonic hypothalamus. In mice, gliogenesis is a pro...

    Authors: Candace M. Marsters, Jessica M. Rosin, Hayley F. Thornton, Shaghayegh Aslanpour, Natasha Klenin, Grey Wilkinson, Carol Schuurmans, Quentin J. Pittman and Deborah M. Kurrasch
    Citation: Neural Development 2016 11:20
    Content type: Research article Published on:

  39. Oculomotor neurons develop initially like typical motor neurons, projecting axons out of the ventral midbrain to their ipsilateral targets, the extraocular muscles. However, in all vertebrates, after the oculo...

    Authors: Brielle Bjorke, Farnaz Shoja-Taheri, Minkyung Kim, G. Eric Robinson, Tatiana Fontelonga, Kyung-Tai Kim, Mi-Ryoung Song and Grant S. Mastick
    Citation: Neural Development 2016 11:18
    Content type: Research article Published on:

  40. The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ...

    Authors: Emilie Legué, Jackie L. Gottshall, Edouard Jaumouillé, Alberto Roselló-Díez, Wei Shi, Luis Humberto Barraza, Senna Washington, Rachel L. Grant and Alexandra L. Joyner
    Citation: Neural Development 2016 11:17
    Content type: Research article Published on:

  41. Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a...

    Authors: William C. Hilinski, Jonathan R. Bostrom, Samantha J. England, José L. Juárez-Morales, Sarah de Jager, Olivier Armant, Jessica Legradi, Uwe Strähle, Brian A. Link and Katharine E. Lewis
    Citation: Neural Development 2016 11:16
    Content type: Research article Published on:

  43. Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ...

    Authors: Torrey L. S. Truszkowski, Eric J. James, Mashfiq Hasan, Tyler J. Wishard, Zhenyu Liu, Kara G. Pratt, Hollis T. Cline and Carlos D. Aizenman
    Citation: Neural Development 2016 11:14
    Content type: Research article Published on:

  44. Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe...

    Authors: Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques and Richard Blouin
    Citation: Neural Development 2016 11:13
    Content type: Research article Published on:

  45. Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as ...

    Authors: Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa and Joshua G. Corbin
    Citation: Neural Development 2016 11:12
    Content type: Research article Published on:

  46. Autism Spectrum Disorders (ASD) are the second most common developmental cause of disability in the United States. ASDs are accompanied with substantial economic and emotional cost. The brains of ASD patients ...

    Authors: Christine Pérez, Darrell Sawmiller and Jun Tan
    Citation: Neural Development 2016 11:11
    Content type: Review Published on:

  47. Retinal ganglion cell (RGC) differentiation in vivo is a highly stereotyped process, likely resulting from the interaction of cell type-specific transcription factors and tissue-derived signaling factors. The ...

    Authors: Paola Lepanto, Camila Davison, Gabriela Casanova, Jose L. Badano and Flavio R. Zolessi
    Citation: Neural Development 2016 11:10
    Content type: Research article Published on:

  48. Brain size and patterning are dependent on dosage-sensitive morphogen signaling pathways – yet how these pathways are calibrated remains enigmatic. Recent studies point to a new role for microRNAs in tempering...

    Authors: Giuliana Caronia-Brown, Angela Anderegg and Rajeshwar Awatramani
    Citation: Neural Development 2016 11:9
    Content type: Research article Published on:

  50. The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiat...

    Authors: Ivan Gladwyn-Ng, Lieven Huang, Linh Ngo, Shan Shan Li, Zhengdong Qu, Hannah Kate Vanyai, Hayley Daniella Cullen, John Michael Davis and Julian Ik-Tsen Heng
    Citation: Neural Development 2016 11:7
    Content type: Short Report Published on:

Editors-in-Chief

Chris Doe
University of Oregon, USA
Julia Kaltschmidt
Stanford University, USA
Beth Stevens
Harvard University, USA

 

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Neural Development

ISSN: 1749-8104