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  1. Research article

    Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern

    The mouse cerebellum (Cb) has a remarkably complex foliated three-dimensional (3D) structure, but a stereotypical cytoarchitecture and local circuitry. Little is known of the cellular behaviors and genes that ...

    Emilie Legué, Jackie L. Gottshall, Edouard Jaumouillé, Alberto Roselló-Díez, Wei Shi, Luis Humberto Barraza, Senna Washington, Rachel L. Grant and Alexandra L. Joyner

    Neural Development 2016 11:17

    Published on: 8 September 2016

  2. Research article

    Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons

    Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in excitation and inhibition in the central nervous system (CNS), leading to diseases. Therefore, the correct specification a...

    William C. Hilinski, Jonathan R. Bostrom, Samantha J. England, José L. Juárez-Morales, Sarah de Jager, Olivier Armant, Jessica Legradi, Uwe Strähle, Brian A. Link and Katharine E. Lewis

    Neural Development 2016 11:16

    Published on: 23 August 2016

  3. Research article

    In vivo functional analysis of Drosophila Robo1 immunoglobulin-like domains

    In animals with bilateral symmetry, midline crossing of axons in the developing central nervous system is regulated by Slit ligands and their neuronal Roundabout (Robo) receptors. Multiple structural domains a...

    Marie C. Reichert, Haley E. Brown and Timothy A. Evans

    Neural Development 2016 11:15

    Published on: 18 August 2016

  4. Research article

    Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits

    Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of ...

    Torrey L. S. Truszkowski, Eric J. James, Mashfiq Hasan, Tyler J. Wishard, Zhenyu Liu, Kara G. Pratt, Hollis T. Cline and Carlos D. Aizenman

    Neural Development 2016 11:14

    Published on: 8 August 2016

  5. Research article

    Dual leucine zipper kinase regulates expression of axon guidance genes in mouse neuronal cells

    Recent genetic studies in model organisms, such as Drosophila, C. elegans and mice, have highlighted a critical role for dual leucine zipper kinase (DLK) in neural development and axonal responses to injury. Howe...

    Andréanne Blondeau, Jean-François Lucier, Dominick Matteau, Lauralyne Dumont, Sébastien Rodrigue, Pierre-Étienne Jacques and Richard Blouin

    Neural Development 2016 11:13

    Published on: 28 July 2016

  6. Research article

    Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei

    Neurons in the hypothalamus function to regulate the state of the animal during both learned and innate behaviors, and alterations in hypothalamic development may contribute to pathological conditions such as ...

    Katie Sokolowski, Tuyen Tran, Shigeyuki Esumi, Yasmin Kamal, Livio Oboti, Julieta Lischinsky, Meredith Goodrich, Andrew Lam, Margaret Carter, Yasushi Nakagawa and Joshua G. Corbin

    Neural Development 2016 11:12

    Published on: 21 May 2016

  7. Short Report

    Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons

    The development of neural circuits within the embryonic cerebral cortex relies on the timely production of neurons, their positioning within the embryonic cerebral cortex as well as their terminal differentiat...

    Ivan Gladwyn-Ng, Lieven Huang, Linh Ngo, Shan Shan Li, Zhengdong Qu, Hannah Kate Vanyai, Hayley Daniella Cullen, John Michael Davis and Julian Ik-Tsen Heng

    Neural Development 2016 11:7

    Published on: 11 March 2016

  8. Reviewer acknowledgement

    Reviewer acknowledgement

    The editors of Neural Development would like to thank all the reviewers who have contributed to the journal in Volume 10 (2015).

    Chris Q. Doe, William Harris, Kang Shen and Rachel Wong

    Neural Development 2016 11:6

    Published on: 8 March 2016

  9. Research article

    Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism

    For neurons to function correctly in neuronal circuitry they must utilize appropriate neurotransmitters. However, even though neurotransmitter specificity is one of the most important and defining properties o...

    José L. Juárez-Morales, Claus J. Schulte, Sofia A. Pezoa, Grace K. Vallejo, William C. Hilinski, Samantha J. England, Sarah de Jager and Katharine E. Lewis

    Neural Development 2016 11:5

    Published on: 19 February 2016

  10. Research article

    Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation

    Nerve growth factor (NGF) is the prototypical target-derived neurotrophic factor required for sympathetic neuron survival and for the growth and ramification of sympathetic axons within most but not all sympat...

    Gerard W. O’Keeffe, Humberto Gutierrez, Laura Howard, Christopher W. Laurie, Catarina Osorio, Núria Gavaldà, Sean L. Wyatt and Alun M. Davies

    Neural Development 2016 11:4

    Published on: 15 February 2016

  11. Research article

    Identification of molecular signatures specific for distinct cranial sensory ganglia in the developing chick

    The cranial sensory ganglia represent populations of neurons with distinct functions, or sensory modalities. The production of individual ganglia from distinct neurogenic placodes with different developmental ...

    Cedric Patthey, Harry Clifford, Wilfried Haerty, Chris P. Ponting, Sebastian M. Shimeld and Jo Begbie

    Neural Development 2016 11:3

    Published on: 27 January 2016

  12. Research article

    Microtubule-associated protein 1b is required for shaping the neural tube

    Shaping of the neural tube, the precursor of the brain and spinal cord, involves narrowing and elongation of the neural tissue, concomitantly with other morphogenetic changes that contribue to this process. In...

    Pradeepa Jayachandran, Valerie N. Olmo, Stephanie P. Sanchez, Rebecca J. McFarland, Eudorah Vital, Jonathan M. Werner, Elim Hong, Neus Sanchez-Alberola, Aleksey Molodstov and Rachel M. Brewster

    Neural Development 2016 11:1

    Published on: 18 January 2016

  13. Research article

    Deltex1 is inhibited by the Notch–Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation

    Notch signaling has been conserved throughout evolution and plays a fundamental role in various neural developmental processes and the pathogenesis of several human cancers and genetic disorders. However, how ...

    Yi-Chuan Cheng, Yin-Cheng Huang, Tu-Hsueh Yeh, Hung-Yu Shih, Ching-Yu Lin, Sheng-Jia Lin, Ching-Chi Chiu, Ching-Wen Huang and Yun-Jin Jiang

    Neural Development 2015 10:28

    Published on: 30 December 2015

  14. Research article

    Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons

    In the auditory brainstem, ventral cochlear nucleus (VCN) axons project to the contralateral, but not ipsilateral, medial nucleus of trapezoid body (MNTB), terminating in the calyx of Held. Dorsal VCN neurons,...

    Mariam L. Abdul-latif, Jesus A. Ayala Salazar, Sonya Marshak, Minhan L. Dinh and Karina S. Cramer

    Neural Development 2015 10:27

    Published on: 15 December 2015

  15. Research Article

    Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons

    In mouse embryos, the Pax6 transcription factor is expressed in the progenitors of thalamic neurons but not in thalamic neurons themselves. Its null-mutation causes early mis-patterning of thalamic progenitors...

    James M. Clegg, Ziwen Li, Michael Molinek, Isabel Martín Caballero, Martine N. Manuel and David J. Price

    Neural Development 2015 10:26

    Published on: 31 October 2015

  16. Research article

    The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm

    In the visual system of most binocular vertebrates, the axons of retinal ganglion cells (RGCs) diverge at the diencephalic midline and extend to targets on both ipsi- and contralateral sides of the brain. Whil...

    Paolo Panza, Austen A. Sitko, Hans-Martin Maischein, Iris Koch, Matthias Flötenmeyer, Gavin J. Wright, Kenji Mandai, Carol A. Mason and Christian Söllner

    Neural Development 2015 10:23

    Published on: 22 October 2015

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