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Fig. 2 | Neural Development

Fig. 2

From: Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation

Fig. 2

The Lrig1-lineage stem cells in the adult brain lateral wall were largely quiescent during juvenile development. A Control analysis of EdU administration in juvenile mice showed complete labeling without disrupting the KI-67+ cell or DCX+ cell numbers. Scale bar, 100 μm. B The EdU signal overlapped completely with the KI-67 signal. Scale bar, 100 μm. C EdU pulse-chase during juvenile development. Number of EdU+ nuclei per mm2. Mean ± standard deviation. D EdU then BrdU double pulse-chase during juvenile development. Mean ± standard deviation. E EdU pulse-chase during juvenile development then tamoxifen induction in adult age. Mean ± standard deviation. F A representative confocal image from one of the ventricular walls quantitated. Scale bar, 10 μm. G EdU pulse-chase during juvenile development then tamoxifen induction shortly after. A representative confocal image. Scale bar, 10 μm. H Additional time points of EdU pulses during juvenile development then tamoxifen induction in adults. Mean ± standard deviation

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Neural Development

ISSN: 1749-8104