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Fig. 1 | Neural Development

Fig. 1

From: Lrig1 expression identifies quiescent stem cells in the ventricular-subventricular zone from postnatal development to adulthood and limits their persistent hyperproliferation

Fig. 1

Quiescent Lrig1-lineage stem cells in the lateral wall of the adult mouse brain. A Control analysis of the Tg(Nr2e1-EGFP)/+ mouse brains. Orthogonal view after whole mount immunofluorescence and confocal microscopy. Scale bar, 10 μm. B An EGFP+ KI-67- ASCL1- cell filling the gap between S100+ ependymal cells, suggesting a B1 type stem cell identity. Scale bar, 10 μm. C The previously identified Lrig1-lineage stem cells largely did not incorporate EdU during one week pulse and did not contact the ventricle with an apical extension. Scale bar, 10 μm. D Analyses of additional mouse strains. E Dot plot of the distributions of the cell body locations. Black bars, mean ± standard deviation. Magenta bar, median. Student’s t test. F Histogram of the same distributions. Kolmogorov-Smirnov test. G Percentages of ventricle-contacting or non-ventricle-contacting cells. Chi-square test

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Neural Development

ISSN: 1749-8104