Skip to main content
Fig. 4 | Neural Development

Fig. 4

From: mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons

Fig. 4

m6A correlates with low translation efficiency and low mRNA stability in neuroblasts. A Loss of m6A does not significantly affect target mRNA abundance. Log2 fold-change in transcript abundance in Mettl3 null brains versus wildtype brains, plotted as the cumulative distribution of m6A targets compared to all larval brain transcripts. B m6A correlates with low translation efficiency (TE). Log2 relative TE (transcript-specific TE / average TE), plotted as the cumulative distribution of m6A targets compared to all larval brain transcripts with matching adult head TE data. C Distribution of mRNA half-lives in neuroblasts and neurons, as determined by EC-tagging pulse-chase. Half-life values greater than 480 min were rounded down to 480 min. D and E m6A correlates with low mRNA half-life in neuroblasts but not neurons. mRNA half-life plotted as the cumulative distribution of m6A targets compared to all mRNAs as measured in neurons (D) or neuroblasts (E). P-values were determined by two sided Kolmogorov–Smirnov tests

Back to article page

Neural Development

ISSN: 1749-8104