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Fig. 3 | Neural Development

Fig. 3

From: mRNAs encoding neurodevelopmental regulators have equal N6-methyladenosine stoichiometry in Drosophila neuroblasts and neurons

Fig. 3

Novel m6A targets and evidence of uniform m6A stoichiometry between neuroblast-biased and neuron-biased brains. A Partial list of novel m6A targets identified in this study. Genes are listed below the cell type they are most associated with (cell cycle and fate determination genes are associated with neuroblasts, neuron identity and axon pathfinding genes are associated with neurons). B IGV plots of two genes with apparent increased m6A frequency in neuroblast-biased brains. A single Mettl3-dependent peak in the 5’UTR of run is outlined in gray. C Heat map comparing neuron-biased / neuroblast-biased (WT / insc > aPKCCAAX) ratios for all m6A targets based on input RNA-seq and meRIP-seq. D RT-qPCR of target transcripts in meRIP RNA versus input RNA. 5S rRNA is a negative control (not a m6A target). Data are average ± SEM for three independent input and meRIP samples

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Neural Development

ISSN: 1749-8104