Fig. 8
From: Early development of the cochlea of the common marmoset, a non-human primate model
Cochlear neuronal development in E70 and E77. (A-E) Cochleovestibular ganglion in E70 cochlea. Expression of TUBB3, ISL1, and NEUROD1 was observed at E70 (A). Expression of POU4F1, SOX2, and PRPH was also observed in E70 cochleovestibular ganglion (B, C, and D). However, expression of MAFB and GATA3 was not detected in E70 cochleovestibular ganglion (D and E). (F-L) Spiral ganglion in E77 cochlea. Expression of TUBB3 and PRPH was observed in E77 spiral ganglion neurons (F). In E77, S100B-positive glial cells surrounding spiral ganglion neurons were observed (F). In E77, expression of NEUROD1 was observed in only an apical turn (asterisk in G), while RBFOX3 expression was observed in basal turns (H). No RBFOX3 expression was observed in the NEUROD1-positive spiral ganglion neurons (I). Expression of GATA3, ISL1, and MAFB was observed in the spiral ganglion neurons in E77 (J-L). The nuclei were counterstained with Hoechst (blue). Scale bar: 50 µm in A-E, G, and I, 100 µm in F, H, and J-L