Fig. 6
From: Early development of the cochlea of the common marmoset, a non-human primate model
OTX2, PAX2, GATA3, and ISL1 expression patterns in E77, E87, and E92 cochlea. (A-D) Expression patterns of E77 cochlea. GATA3 and OTX2 expression was observed in the ventral and dorsal portion of the cochlear duct at E77, respectively (A). In the cochlear duct, ISL1 and PAX2 expression was observed in the ventral (B) and lateral portion (C), respectively. OTX1 expression diminished and no expression was detected in E77 (D). (E–G) Expression patterns in E87 cochlea. GATA3 and OTX2 expression was observed in the ventral and dorsal portion of the cochlear duct, respectively (E). ISL1 expression was observed in the ventral portion of the cochlear duct (F). PAX2 expression was detected in the lateral portion of the cochlear duct and hair cells (arrow in G). (H-J) Expression patterns in E92 cochlea. GATA3 and OTX2 expression was observed in the ventral and dorsal portion of the cochlear duct, respectively (H). ISL1 expression was observed in the ventral portion of the cochlear duct (I). PAX2 expression was detected in the lateral portion of the cochlear duct and hair cells (arrow in J). The nuclei were counterstained with Hoechst (blue). Scale bar: 100 µm in A-D, 50 µm in E-J. SpGN: spiral ganglion neuron