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Fig. 6 | Neural Development

Fig. 6

From: The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination

Fig. 6

Loss of Gpr62 does not grossly alter myelin thickness or extent in the CNS. A Representative transmission electron microscopy images of myelinated axons in the optic nerve, spinal cord and corpus callosum at 8 weeks of age in Gpr62WT/WT and Gpr62KO/KO mice. Scale bars: 1 μm. B Assessment of the proportion of axons myelinated in each region at 3, 8 and 26 weeks of age. No significant difference was observed in the proportion of axons myelinated between Gpr62WT/WT and Gpr62KO/KO mice at any age. C G-ratio analysis of myelin thickness in the 3 and 8-week old optic nerve of wild-types and knockouts indicates normal myelin thickness in the Gpr62KO/KO animals. Quantified in (D) based on n = 3 mice per condition, 200–300 myelinated axons assessed per animal

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