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Fig. 5 | Neural Development

Fig. 5

From: The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination

Fig. 5

Loss of Gpr62 does not grossly disrupt myelin formation in the brain. A Representative black gold staining of coronal brain hemisections of 8-week old Gpr62WT/WT and Gpr62KO/KO mice. The overall intensity and distribution of black gold stained myelin is similar between each genotype. Scale bar: 1 mm. B Western blot analysis of myelin proteins MBP and PLP in whole brain lysates from 8-week old Gpr62 wild-type and knockouts. Quantified in (C) relative to beta tubulin (TUBB) as a control for protein loading (p > 0.05 for both comparisons). D Representative images of the optic nerves of an 8-week old Gpr62WT/WT and Gpr62KO/KO mouse stained with the paranodal marker Caspr and nodal marker Nav1.6. Scale bar: 10 μm

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