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Fig. 2 | Neural Development

Fig. 2

From: The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination

Fig. 2

Gpr62-Flag expression is localized to the adaxonal myelin surface. A, B AAV-pMBP-Gpr62 expression in the striatum with expressing myelin sheaths caught in cross section. Sections were co-stained with anti-MBP (compact myelin, A) or anti-MAG (adaxonal myelin and inner tongue, B). C-D Profile of staining intensity for Gpr62-Flag, MBP and MAG in representative myelin segments. Gpr62-Flag expression in a myelin sheath was typically internal to the majority of MBP staining (C), but showed a near perfect co-localization with MAG (D), consistent with an adaxonal localization of Gpr62-Flag protein. Scale bars: 10 μm

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Neural Development

ISSN: 1749-8104