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Fig. 1 | Neural Development

Fig. 1

From: Cellular response to spinal cord injury in regenerative and non-regenerative stages in Xenopus laevis

Fig. 1

Cellular response to injury in Regenerative Stage. a Cartoon of spinal cord injury in NF stage 50. b, c Semithin sections of the b rostral and c caudal stumps at 2 days post transection (dpt) stained with methylene blue. Arrowheads in panel C showed macrophages. d-i; k-m; o-s; u, v Correspond to ultrathin sections observed by transmission electron microscopy. d-i Different regions of the spinal cord at 2 dpt; d cells lining the central canal (cc) closing the rostral stump (black arrowhead); e mitochondrial swelling (black arrow) observed in cells from panel D; black arrowheads depict the separation between two cells; f, g mitotic clusters of cells (yellow shadow); h cell undergoing extrusion (purple shadow); i macrophage from panel C from the injured site. j Semithin section at 6 dpt. k-m Different regions of the spinal cord at 6 dpt; k cells in the central canal of the caudal stump (green shadow), without contact with ependymal cells (black arrowheads); l synaptic density (black arrowheads) and synaptic vesicles (white arrowheads); m cells forming a rosette structure in the ablation gap (red shadow). n Semithin section at 10 dpt. o-s Different regions of the spinal cord at 10 dpt; o a bundle of unmyelinated axons surrounded by ependymal cells (black arrowheads); p unmyelinated axon (orange shadow), and synaptic vesicles (white arrowheads); q desmosome junction (black arrowhead) between ependymal cells next to unmyelinated axons; r a myelinated axon (white arrowhead) in the cc of the caudal stump; s neuronal nuclei in the cc of the caudal stump (black arrowhead). t Semithin section at 20 dpt. u-w Different regions of the spinal cord at 20 dpt; u cells in the cc (red line); v ependymal cells with regular shape in the regenerated spinal cord with apical mitochondria (m); w desmosome junctions between the regenerated ependymal cells (black arrowheads). The red dotted lines indicate the injured site (a, b, c, j, n, t)

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