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Fig. 5 | Neural Development

Fig. 5

From: A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage

Fig. 5

Kr/Pdm induces ectopic motor neurons targeting ventral oblique muscles. (A-C) Kr/Pdm overexpression results in ectopic motor neuron projections to the ventral oblique muscles (arrowhead). (A) Controls (NB7–1-gal4 UAS-myr:GFP) show NB7–1 progeny innervating the ventral oblique muscle (ISNd). (A’) Enlargement of boxed region in A. (A") GFP marking NB7–1 progeny; (A"‘) FasII marking all motor axons. (B) Kr/Pdm overexpression (NB7–1-gal4 UAS-myr:GFP UAS-Kr UAS-Pdm) induces ectopic VO motor neuron projections to the ventral oblique muscles (arrow). Scale bar: 10 μm. (C) Quantification. See Fig. S2 for methods. (D) Kr/Pdm overexpression analyzed by single neuron MCFO showing two motor neurons projecting to the ventral oblique muscles. (D’) Enlargement of boxed region in D. (D", D"‘) Individual motor neurons labeled with V5 or HA projecting to ventral oblique muscles. Scale bar: 10 μm

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