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Fig. 4 | Neural Development

Fig. 4

From: A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage

Fig. 4

Kr/Pdm co-expression induces ectopic Nkx6+ VO motor neuron molecular identity. a-c Kr/Pdm overexpression (OE) induces ectopic Nkx6+ VO motor neurons. (A) Control lineages (NB7–1-Gal4 UAS-myr:GFP) have one Nkx6+ Eve− VO motor neuron (yellow arrow). b Kr/Pdm overexpression (NB7–1-Gal4 UAS-myr:GFP UAS-Kr UAS-Pdm) increases the number of Nkx6+ Eve− VO motor neurons. c Quantification. Asterisk, GFP-negative EL neurons from NB3–3. Scale bar: 10 μm. d-f Kr/Pdm overexpression (OE) reduces Eve+ motor neurons. d Control lineages (NB7–1-Gal4 UAS-myr:GFP) have five Eve+ motor neurons including Hb+ U1/U2 and Runt+ U4/U5. e Kr/Pdm overexpression (NB7–1-Gal4 UAS-myr:GFP UAS-Kr UAS-Pdm) reduces the number of Eve+ U4/U5 motor neurons. f Quantification. Scale bar: 10 μm. g Summary

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Neural Development

ISSN: 1749-8104