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Fig. 2 | Neural Development

Fig. 2

From: A novel temporal identity window generates alternating Eve+/Nkx6+ motor neuron subtypes in a single progenitor lineage

Fig. 2

NB7–1 generates a motor neuron that innervates ventral oblique muscles. (A) NB7–1 DiI clone (red) generated as described in Schmid et al. (1999). Green bracket, U1-U5 motor neurons innervating dorsal and lateral longitudinal muscles; magenta bracket, unknown neuron(s) innervating more ventral muscles. Scale bar: 7 μm. (B-B″) NB7–1 lineage marked by GFP (green) stained for the motor axon marker FasII (blue). Stage 17; one hemisegment shown; ventral midline, dashed at left; dorsal to the right. The NB7–1 lineage produces motor neurons branching out to innervate dorsal and lateral longitudinal muscles (green bracket) and ventral muscles (magenta bracket), similar to the DiI clone in panel A. Scale bar: 10 μm. (C) Schematic of muscle groups, including the ventral oblique muscles (magenta) and the dorsal and lateral longitudinal muscles (green). The U1-U5 motor neurons of the NB7–1 lineage project to dorsal and lateral longitudinal muscle targets through the ISN (black line), while an unidentified subset of NB7–1 progeny project to ventral oblique muscle targets through ISNd (dashed line)

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