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Fig. 2 | Neural Development

Fig. 2

From: Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease

Fig. 2

HUWE1 regulates neural development. (a and b) Shown to the left are diagrams of sagittal section of mouse brain. Boxes indicate a portion of (a) cerebral cortex and (b) cerebellar cortex. Center is a schematic of Huwe1 expression in neural progenitors that are proliferating, differentiating and migrating during development in (a) cerebral cortex and (b) cerebellar cortex (white = low expression, black = high expression). To the right are molecular pathways Huwe1 regulates to affect progenitor development in (a) cerebral cortex and (b) cerebellar cortex. Note that in the cerebellum Huwe1 potentially affects two pathways in different GNP populations. c Shown is a schematic of Q neuroblast migration in C. elegans which is mediated by Wnt signaling. To the left is the molecular mechanism by which EEL-1 and HUWE1 influence Wnt signaling in neuroblast migration and mammalian cell-based assays

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