Fig. 8
From: Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells
Model of ECR9 and ECR65 roles in cone/HC regulatory network. (a) Cell populations with ECR9 and ECR65 activity in relation to populations marked by previously published elements and OC1-associated elements reported here. Vsx2 ECR4 is active in the multipotent RPC population, whereas OC1 ECR9, OC1 ECR65, ThrbCRM1, and ThrbICR are all active in fate-restricted RPC populations. (b) Molecular events upstream and downstream of ECR9 and ECR65 activity. Multipotent RPCs give rise ultimately to RPC [CH] s, which corresponds to a down-regulation of Vsx2 and an upregulation of OC1 and Otx2. The bHLH factors that are sufficient to activate ECR9 and ECR65 reporter expression are shown